M
Michael Hull
Researcher at Yale University
Publications - 24
Citations - 3882
Michael Hull is an academic researcher from Yale University. The author has contributed to research in topics: Endosome & Endocytosis. The author has an hindex of 16, co-authored 24 publications receiving 3681 citations. Previous affiliations of Michael Hull include Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Developmental regulation of MHC class II transport in mouse dendritic cells
Philippe Pierre,Shannon J. Turley,Evelina Gatti,Michael Hull,Joseph Meltzer,Asra Mirza,Kayo Inaba,Ralph M. Steinman,Ira Mellman +8 more
TL;DR: It is found that although early DCs could not present antigen immediately after uptake, efficient presentation of the previously internalized antigen occurred after maturation, 24–48 hours later, a property crucial to their role in immune surveillance.
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The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway.
TL;DR: It is found that overexpression of wild-type rab4 had differential effects on the endocytic pathway, and rab4 appears to control the function or formation of endosomes involved in recycling.
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The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions.
TL;DR: The data from these experiments permitted the construction of a testable, mathematical model which enabled a dissection of the roles of early and recycling endosomes in polarized receptor transport, and contrary to expectations, the majority (>65%) of recycling to the basolateral surface is likely to occur from early endosome, but with relatively little sorting of apical from Basolateral proteins.
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Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling.
TL;DR: The tetraspanins CD9 and CD82 suppress Wnt signaling by promoting the discharge of β-catenin from cells.