K
Kai Simons
Researcher at Max Planck Society
Publications - 438
Citations - 97845
Kai Simons is an academic researcher from Max Planck Society. The author has contributed to research in topics: Golgi apparatus & Membrane protein. The author has an hindex of 147, co-authored 426 publications receiving 93178 citations. Previous affiliations of Kai Simons include European Bioinformatics Institute & Minerva Foundation Institute for Medical Research.
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Journal ArticleDOI
Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
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Lipid rafts and signal transduction
Kai Simons,Derek Toomre +1 more
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.
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Lipid Rafts As a Membrane-Organizing Principle
Daniel Lingwood,Kai Simons +1 more
TL;DR: The evidence for how this principle combines the potential for sphingolipid-cholesterol self-assembly with protein specificity to selectively focus membrane bioactivity is reviewed.
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Solubilization of membranes by detergents
Ari Helenius,Kai Simons +1 more
TL;DR: This review focuses on work that deals with the mechanisms of detergent action in membrane solubilization including properties of detergents model lipid systems and detergent-protein interactions; in addition a possible sequence of events when deterGents interact with biological membranes receives attention.
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Model systems, lipid rafts, and cell membranes.
Kai Simons,Winchil L.C. Vaz +1 more
TL;DR: This review critically analyzes what is known of phase behavior and liquid-liquid immiscibility in model systems and compares these data with what isknown of domain formation in cell membranes.