Michael Imelfort

TL;DR: An objective measure of genome quality is proposed that can be used to select genomes suitable for specific gene- and genome-centric analyses of microbial communities and is shown to provide accurate estimates of genome completeness and contamination and to outperform existing approaches.

TL;DR: Refining a marker set for lineage-specific Gene Loss and Duplication Estimates under Opal Stop Codon Recodings and Mean absolute error of completeness and contamination estimates determined using different universal- and domain-specific marker gene sets.

TL;DR: Metagenomic, single-cell genomic and metatranscriptomic analyses combined with bioreactor performance and 13C- and 15N-labelling experiments show that ANME-2d is capable of independent AOM through reverse methanogenesis using nitrate as the terminal electron acceptor and Comparative analyses reveal that the genes for nitrate reduction were transferred laterally from a bacterial donor, suggesting selection for this novel process within ANME -2d.

TL;DR: A tool for homopolymer error-correction that has greater scalability than existing tools and a quicker but less sensitive statistical approach to distinguish between error and genuine sequence differences is developed.

TL;DR: GroopM is introduced, an automated binning tool that primarily uses differential coverage to obtain high fidelity population genomes from related metagenomes and it is shown that GroopM produces results comparable with more time consuming, labor-intensive methods.