M
Michael J. Bennett
Researcher at University of California, Davis
Publications - 22
Citations - 817
Michael J. Bennett is an academic researcher from University of California, Davis. The author has contributed to research in topics: Transfection & Liposome. The author has an hindex of 12, co-authored 22 publications receiving 803 citations. Previous affiliations of Michael J. Bennett include University of California.
Papers
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Journal ArticleDOI
Transfer and Expression of Foreign Genes in Mammalian Cells
Alessia Colosimo,Kaarin K. Goncz,A. R. Holmes,Karl Kunzelmann,Giuseppe Novelli,Robert W. Malone,Michael J. Bennett,Dieter C. Gruenert +7 more
TL;DR: The transfer of foreign genes into eukaryotic cells, in particular mammalian cells, has been essential to the understanding of the functional significance of genes and regulatory sequences as well as the development of gene therapy strategies.
Journal Article
Structural and functional analysis of cationic transfection lipids: The hydrophobic domain
Rajiv P. Balasubramaniam,Michael J. Bennett,Alfred M. Aberle,Jill G. Malone,Michael H. Nantz,Robert W. Malone +5 more
TL;DR: Modifications in the hydrophobic domain of a prototypic cytofectin (DORI) that incorporate a hydroxyethylammonium moiety in the polar domain were found to enhance in vivo gene delivery relative to free DNA.
Journal ArticleDOI
Cationic lipid-mediated gene delivery to murine lung: Correlation of lipid hydration with in vivo transfection activity
Michael J. Bennett,Alfred M. Aberle,Rajiv P. Balasubramaniam,Jill G. Malone,Robert W. Malone,Michael H. Nantz +5 more
TL;DR: The hydration data suggest that the more effective transfection lipids for mouse lung delivery are those possessing the greatest imbalance between the cross-sectional areas occupied by the polar and hydrophobic domains.
Journal ArticleDOI
Cholesterol enhances cationic liposome-mediated DNA transfection of human respiratory epithelial cells.
Michael J. Bennett,Michael H. Nantz,Rajiv P. Balasubramaniam,Dieter C. Gruenert,Robert W. Malone +4 more
TL;DR: Cholesterol was found to enhance lipid-mediated transfection in both the respiratory epithelial cells and mouse fibroblasts, and therefore may be useful for examining gene regulation in various cell types and for developing pulmonary gene therapy.
Patent
Cationic transport reagents
TL;DR: For use in transporting biologically active species into and through membrane barriers, a symmetrical cationic diamine compound having general structure (I) wherein m = 1-10 is required as mentioned in this paper.