M
Michael J. Berridge
Researcher at Babraham Institute
Publications - 222
Citations - 70299
Michael J. Berridge is an academic researcher from Babraham Institute. The author has contributed to research in topics: Inositol & Calcium. The author has an hindex of 100, co-authored 222 publications receiving 68051 citations. Previous affiliations of Michael J. Berridge include University of Cambridge.
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Inositol trisphosphate and calcium signalling
TL;DR: Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle.
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Inositol trisphosphate, a novel second messenger in cellular signal transduction.
TL;DR: Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.
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The versatility and universality of calcium signalling
TL;DR: The universality of calcium as an intracellular messenger depends on its enormous versatility, which is exploited to control processes as diverse as fertilization, proliferation, development, learning and memory, contraction and secretion.
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Calcium signalling: dynamics, homeostasis and remodelling
TL;DR: The Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics and has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
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Inositol phosphates and cell signalling
TL;DR: The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.