M
Michael J. Berridge
Researcher at Babraham Institute
Publications - 222
Citations - 70299
Michael J. Berridge is an academic researcher from Babraham Institute. The author has contributed to research in topics: Inositol & Calcium. The author has an hindex of 100, co-authored 222 publications receiving 68051 citations. Previous affiliations of Michael J. Berridge include University of Cambridge.
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Journal ArticleDOI
Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.
TL;DR: It is shown directly that Ins1,4,5P3 rapidly releases Ca2+ from a microsomal fraction of rat insulinoma but not from mitochondria or secretory granules, suggesting that Ins2+ mobilization from internal pools is not mediated.
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Smooth muscle cell calcium activation mechanisms
TL;DR: The changes in membrane potential induced by these cytosolic oscillators does not drive contraction directly but it functions to couple together individual oscillators to provide the synchronization that is a characteristic feature of many tonic SMCs.
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Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores
TL;DR: It is reported here that the InsP3-sensitive store in hepatocytes discharges spontaneously when overloaded with Ca2+.
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Calcium hypothesis of Alzheimer's disease.
TL;DR: The calcium hypothesis of AD explores how activation of the amyloidogenic pathway may function to remodel the neuronal Ca2+ signaling pathways responsible for cognition to result in the learning and memory deficits that occur early during the onset of AD.