Journal ArticleDOI
The versatility and universality of calcium signalling
TLDR
The universality of calcium as an intracellular messenger depends on its enormous versatility, which is exploited to control processes as diverse as fertilization, proliferation, development, learning and memory, contraction and secretion.Abstract:
The universality of calcium as an intracellular messenger depends on its enormous versatility. Cells have a calcium signalling toolkit with many components that can be mixed and matched to create a wide range of spatial and temporal signals. This versatility is exploited to control processes as diverse as fertilization, proliferation, development, learning and memory, contraction and secretion, and must be accomplished within the context of calcium being highly toxic. Exceeding its normal spatial and temporal boundaries can result in cell death through both necrosis and apoptosis.read more
Citations
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Journal ArticleDOI
Calcium signalling: dynamics, homeostasis and remodelling
TL;DR: The Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics and has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
Journal ArticleDOI
Regulation of cell death: the calcium-apoptosis link.
TL;DR: The dual role of Ca2+ in living organisms is discussed in this paper, where it has been shown that cellular Ca 2+ overload, or perturbation of intracellular Ca2 + compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.
Journal ArticleDOI
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
Hiroshi Takayanagi,Sunhwa Kim,Takako Koga,Takako Koga,Hiroshi Nishina,Masashi Isshiki,Hiroki Yoshida,Hiroki Yoshida,Akio Saiura,Miho Isobe,Miho Isobe,Taeko Yokochi,Jun-ichiro Inoue,Erwin F. Wagner,Tak W. Mak,Tatsuhiko Kodama,Tadatsugu Taniguchi +16 more
TL;DR: RANKL selectively induces NFATc1 expression via TRAF6 and c-Fos signaling pathways, and may represent a master switch for regulating terminal differentiation of osteoclasts, functioning downstream of RANKL.
Journal ArticleDOI
Endoplasmic reticulum stress: cell life and death decisions
TL;DR: Important roles for ER-initiated cell death pathways have been recognized for several diseases, including hypoxia, ischemia/reperfusion injury, neurodegeneration, heart disease, and diabetes.
Journal ArticleDOI
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.
Helmut Sies,Dean P. Jones +1 more
TL;DR: This work focuses on ROS at physiological levels and their central role in redox signalling via different post-translational modifications, denoted as ‘oxidative eustress’.
References
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Journal ArticleDOI
Inositol trisphosphate and calcium signalling
TL;DR: Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle.
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A model for receptor-regulated calcium entry
TL;DR: A capacitative model is proposed for the mechanism by which activation of surface membrane receptors causes sustained Ca2+ entry into cells from the extracellular space, which allows forCa2+ release and Ca2-mobilization to be controlled by a single messenger, inositol (1,4,5) trisphosphate.
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Three-dimensional segregation of supramolecular activation clusters in T cells
TL;DR: The three-dimensional distribution of receptors and intracellular proteins that cluster at the contacts between T cells and APCs during antigen-specific interactions, Surprisingly, instead of showing uniform oligomerization, these proteins clustered into segregated three- dimensional domains within the cell contacts.
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Bcl-2 and the regulation of programmed cell death
TL;DR: The bcl-2 gene has emerged as a critical regulator of PCD in a variety of physiological and pathological contexts and can contribute to the pathogenesis of many diseases ranging from cancer to AIDS.
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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
TL;DR: The results indicate that the Bcl-2 family of proteins bind to the VDAC in order to regulate the mitochondrial membrane potential and the release of cytochrome c during apoptosis.