M
Michael J. Brennan
Researcher at Center for Biologics Evaluation and Research
Publications - 76
Citations - 5286
Michael J. Brennan is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 40, co-authored 75 publications receiving 5015 citations. Previous affiliations of Michael J. Brennan include Aeras.
Papers
More filters
Journal ArticleDOI
The heparin-binding haemagglutinin of M. tuberculosis is required for extrapulmonary dissemination
Kevin Pethe,Sylvie Alonso,Franck Biet,Giovanni Delogu,Michael J. Brennan,Camille Locht,Franco D. Menozzi +6 more
TL;DR: Evidence is provided that adhesins such as HBHA are required for extrapulmonary dissemination, and that interactions with non-phagocytic cells have an important role in the pathogenesis of tuberculosis.
Journal ArticleDOI
Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cells
Elizabeth Leininger,Mark E. Roberts,James G. Kenimer,Ian G. Charles,Neil F. Fairweather,Pavel Novotny,Michael J. Brennan +6 more
TL;DR: It is demonstrated that purified preparations of the 69-kDa outer membrane protein can promote the attachment of Chinese hamster ovary (CHO) cells and the name "pertactin" is proposed for this protein, which is proposed as a replacement for B. pertussis to mammalian cells.
Journal ArticleDOI
Evidence that mycobacterial PE_PGRS proteins are cell surface constituents that influence interactions with other cells.
Michael J. Brennan,Giovanni Delogu,Yiping Chen,Stoyan Bardarov,Jordan Kriakov,Mohammad Alavi,William R. Jacobs +6 more
TL;DR: It is demonstrated that a transposon insertion in a PE_PGRS gene (1818PE_ PGRS) found in Mycobacterium bovis BCG Pasteur, which is the BCG homologue of the M. tuberculosis H37Rv gene Rv1818c, introduces new phenotypic properties to this BCG strain.
Journal ArticleDOI
PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX-5
Abdallah M. Abdallah,Theo Verboom,Eveline M. Weerdenburg,Nicolaas C. Gey van Pittius,Phetole Walter Mahasha,Connie R. Jimenez,Marcela Parra,Nathalie Cadieux,Michael J. Brennan,Ben J. Appelmelk,Wilbert Bitter +10 more
TL;DR: The data show that ESX‐5 is probably a major secretion pathway for mycobacteria and that this system is responsible for the secretion of recently evolved PE_PGRS and PPE proteins.
Journal ArticleDOI
The PE multigene family: a ‘molecular mantra’ for mycobacteria
TL;DR: Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in myc Cobacteria.