M
Michael J. McDonald
Researcher at Monash University
Publications - 34
Citations - 1985
Michael J. McDonald is an academic researcher from Monash University. The author has contributed to research in topics: Population & Experimental evolution. The author has an hindex of 16, co-authored 28 publications receiving 1407 citations. Previous affiliations of Michael J. McDonald include Academia Sinica & Monash University, Clayton campus.
Papers
More filters
Journal ArticleDOI
The dynamics of molecular evolution over 60,000 generations
Benjamin H. Good,Michael J. McDonald,Michael J. McDonald,Jeffrey E. Barrick,Richard E. Lenski,Michael M. Desai +5 more
TL;DR: The dynamics of molecular evolution in twelve experimental populations of Escherichia coli are analysed, using whole-genome metagenomic sequencing at five hundred-generation intervals through sixty thousand generations to show that long-term adaptation to a constant environment can be a more complex and dynamic process than is often assumed.
Journal ArticleDOI
Sex speeds adaptation by altering the dynamics of molecular evolution
TL;DR: It is demonstrated that sex both speeds adaptation and alters its molecular signature by allowing natural selection to more efficiently sort beneficial from deleterious mutations.
Journal ArticleDOI
Adaptive Divergence in Experimental Populations of Pseudomonas fluorescens. IV. Genetic Constraints Guide Evolutionary Trajectories in a Parallel Adaptive Radiation
TL;DR: Two new mutational pathways are identified that allow realization of the WS phenotype: in common with the Wsp module these pathways contain a di-guanylate cyclase-encoding gene subject to negative regulation.
Journal ArticleDOI
Clusters of Nucleotide Substitutions and Insertion/Deletion Mutations Are Associated with Repeat Sequences
TL;DR: The authors propose that short repeat sequences may play an important role in causing the pervasive clustering of mutations across diverse genomes from prokaryotes to humans.
Journal ArticleDOI
Diverse hydrogen production and consumption pathways influence methane production in ruminants.
Chris Greening,Renae R Geier,Cecilia Wang,Laura C. Woods,Sergio E. Morales,Michael J. McDonald,Rowena Rushton-Green,Xochitl C. Morgan,Satoshi Koike,Sinead C. Leahy,William J. Kelly,Isaac Cann,Graeme T. Attwood,Gregory M. Cook,Roderick I. Mackie +14 more
TL;DR: H2 metabolism is a more complex and widespread trait among rumen microorganisms than previously recognised and may help to inform ongoing strategies to mitigate methane emissions by increasing flux through alternative H2 uptake pathways, including through animal selection, dietary supplementation and methanogenesis inhibitors.