S
Sinead C. Leahy
Researcher at AgResearch
Publications - 64
Citations - 3679
Sinead C. Leahy is an academic researcher from AgResearch. The author has contributed to research in topics: Rumen & Genome. The author has an hindex of 26, co-authored 59 publications receiving 2997 citations. Previous affiliations of Sinead C. Leahy include University College Cork & National University of Ireland.
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Journal ArticleDOI
Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor
Mary O'Connell Motherway,Aldert Zomer,Sinead C. Leahy,Justus Reunanen,Francesca Bottacini,Marcus J. Claesson,Frances O'Brien,Kiera Flynn,Pat G. Casey,José Antonio Moreno Muñoz,Breda Kearney,Aileen Houston,Caitlin O'Mahony,Des Higgins,Fergus Shanahan,Airi Palva,Willem M. de Vos,Gerald F. Fitzgerald,Marco Ventura,Paul W. O'Toole,Douwe van Sinderen +20 more
TL;DR: Transcriptome analysis of the Bifidobacterium breve UCC2003 genome revealed differential expression of a type IVb tight adherence (Tad) pilus-encoding gene cluster designated “tad2003,” andMutational analysis demonstrated that the tad2003 gene cluster is essential for efficient in vivo murine gut colonization, and immunogold transmission electron microscopy confirmed the presence of Tad pili at the poles of B. breve
Journal ArticleDOI
Getting better with bifidobacteria
TL;DR: The role that Bifidobacterium species play as a prominent probiotic component of the authors' gastrointestinal microflora is discussed and some forthcoming insights into the general characteristics of B ifidobacteria genomes are provided.
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Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection
Rekha Seshadri,Sinead C. Leahy,Graeme T. Attwood,Koon Hoong Teh,Suzanne C. Lambie,Adrian L. Cookson,Emiley A. Eloe-Fadrosh,Georgios A. Pavlopoulos,Michalis Hadjithomas,Neha Varghese,David Paez-Espino,Rechelle Perry,Gemma Henderson,Christopher J. Creevey,Nicolas Terrapon,Nicolas Terrapon,Pascal Lapébie,Pascal Lapébie,Elodie Drula,Elodie Drula,Vincent Lombard,Vincent Lombard,Edward M. Rubin,Nikos C. Kyrpides,Bernard Henrissat,Bernard Henrissat,Bernard Henrissat,Tanja Woyke,Natalia Ivanova,William J. Kelly +29 more
TL;DR: Comparison with the human microbiome revealed rumen-specific enrichment for genes encoding de novo synthesis of vitamin B12, ongoing evolution by gene loss and potential vertical inheritance of the rumen microbiome based on underrepresentation of markers of environmental stress.
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The genome sequence of the rumen methanogen Methanobrevibacter ruminantium reveals new possibilities for controlling ruminant methane emissions.
Sinead C. Leahy,William J. Kelly,Eric Altermann,Ron S. Ronimus,Carl J. Yeoman,Diana M. Pacheco,Dong Li,Zhanhao Kong,Sharla Mctavish,Carrie Sang,Suzanne C. Lambie,Peter H. Janssen,Debjit Dey,Graeme T. Attwood +13 more
TL;DR: The M1 genome sequence provides new insights into the lifestyle and cellular processes of this important rumen methanogen and represents a significant contribution to worldwide efforts to mitigate ruminant methane emissions and reduce production of anthropogenic greenhouse gases.
Journal ArticleDOI
Methane yield phenotypes linked to differential gene expression in the sheep rumen microbiome
Weibing Shi,Christina D. Moon,Sinead C. Leahy,Dongwan D. Kang,Dongwan D. Kang,Jeff Froula,Jeff Froula,Sandra Kittelmann,Christina Fan,Christina Fan,Samuel Deutsch,Samuel Deutsch,Dragana Gagic,Henning Seedorf,William J. Kelly,Renee Atua,Carrie Sang,Priya Soni,Dong Li,C. S. Pinares-Patiño,John C. McEwan,Peter H. Janssen,Feng Chen,Feng Chen,Axel Visel,Zhong Wang,Zhong Wang,Zhong Wang,Graeme T. Attwood,Edward M. Rubin,Edward M. Rubin +30 more
TL;DR: A discrete set of rumen methanogens whose methanogenesis pathway transcription profiles correlate with methane yields are identified and provide new targets for CH4 mitigation at the levels of microbiota composition and transcriptional regulation.