M
Michael J. Mullen
Researcher at St Bartholomew's Hospital
Publications - 120
Citations - 9541
Michael J. Mullen is an academic researcher from St Bartholomew's Hospital. The author has contributed to research in topics: Stenosis & Aortic valve. The author has an hindex of 36, co-authored 110 publications receiving 8633 citations. Previous affiliations of Michael J. Mullen include Barts Health NHS Trust & University College Hospital.
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Journal ArticleDOI
Prospective Study of Heart Rate Variability and Mortality in Chronic Heart Failure Results of the United Kingdom Heart Failure Evaluation and Assessment of Risk Trial (UK-Heart)
James Nolan,P D Batin,R. Andrews,Steven Lindsay,P Brooksby,Michael J. Mullen,Wazir Baig,Andrew D. Flapan,Alan J. Cowley,Robin J Prescott,James M.M. Neilson,Keith A.A. Fox +11 more
TL;DR: CHF is associated with autonomic dysfunction, which can be quantified by measuring HRV, and a reduction in SDNN identifies patients at high risk of death and is a better predictor of death due to progressive heart failure than other conventional clinical measurements.
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Long-term outcomes after transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis: the U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry.
Neil Moat,Peter Ludman,Mark A. de Belder,Ben Bridgewater,Andrew D. Cunningham,Christopher Young,Martyn Thomas,Jan Kovac,Tom Spyt,Philip MacCarthy,Olaf Wendler,David Hildick-Smith,Simon W. Davies,Uday Trivedi,Daniel J. Blackman,Richard D. Levy,Stephen Brecker,Andreas Baumbach,Tim Daniel,Huon Gray,Michael J. Mullen +20 more
TL;DR: Midterm to long-term survival after TAVI was encouraging in this high-risk patient population, although a substantial proportion of patients died within the first year.
Journal ArticleDOI
Exercise intolerance in adult congenital heart disease: comparative severity, correlates, and prognostic implication.
Gerhard-Paul Diller,Konstantinos Dimopoulos,Darlington O. Okonko,Wei Li,Sonya V. Babu-Narayan,Craig S. Broberg,Bengt Johansson,Beatriz Bouzas,Michael J. Mullen,Philip A. Poole-Wilson,Darrel P. Francis,Michael A. Gatzoulis +11 more
TL;DR: Exercise capacity is depressed in ACHD patients (even in allegedly asymptomatic patients) on a par with chronic heart failure subjects and is related to the frequency and duration of hospitalization.
Journal ArticleDOI
Mental Stress Induces Transient Endothelial Dysfunction in Humans
Lorenzo Ghiadoni,Ann E. Donald,Mark Cropley,Michael J. Mullen,G. Oakley,Mia Taylor,Georgina O’Connor,John Betteridge,Nigel Klein,Andrew Steptoe,John E. Deanfield +10 more
TL;DR: These findings suggest that brief episodes of mental stress, similar to those encountered in everyday life, may cause transient endothelial dysfunction in healthy young individuals and might represent a mechanistic link between mental stress and atherogenesis.
Journal ArticleDOI
Acute systemic inflammation impairs endothelium-dependent dilatation in humans.
Aroon D. Hingorani,Jenny M. Cross,Rajesh K. Kharbanda,Michael J. Mullen,K Bhagat,Mia Taylor,Ann E. Donald,Miriam Palacios,George E. Griffin,John E. Deanfield,Raymond J. MacAllister,Patrick Vallance +11 more
TL;DR: S typhi vaccine generates a mild inflammatory reaction associated with temporary but profound dysfunction of the arterial endothelium in both resistance and conduit vessels to both physical and pharmacological dilator stimuli, which might explain the association between infection and inflammation and the enhanced risk of an acute cardiovascular event.