Michael J. Nemeth

TL;DR: UBE1L is proposed as a direct pharmacological target that overcomes oncogenic effects of PML/RARα by triggering its degradation and signaling apoptosis in APL cells.

TL;DR: Two parallel cell culture approaches for examining the effects of heavy metals on expression and activation of specific transcription factors known to be involved in regulation of susceptible inducible genes are developed and significant but different effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding are observed.

TL;DR: The hydrophobic heptad sequences of the coiled‐coil sequences are redesigned to generate soluble forms of both the pseudo‐high affinity and the intermediate affinity heterodimeric IL‐2 receptors.

TL;DR: Results indicate that a relatively small cis-acting element is able to enhance remodeling of promoter chromatin structure resulting in increased beta-globin gene expression.

TL;DR: Results indicate that the HSFE is able to augment the opening of β-globin promoter chromatin structure and significantly increase gene expression in the context of an integrated retroviral vector.