M
Michael J. Schell
Researcher at University of South Florida
Publications - 310
Citations - 19555
Michael J. Schell is an academic researcher from University of South Florida. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 75, co-authored 293 publications receiving 17926 citations. Previous affiliations of Michael J. Schell include University of Massachusetts Medical School & University of Cambridge.
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D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.
TL;DR: D-Serine appears to be the endogenous ligand for the glycine site of NMDA receptors, suggesting a mechanism by which astrocyte-derived D-serine could modulate neurotransmission.
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Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity
TL;DR: Using antibodies that react selectively with peptide sequences unique to endothelial nitric oxide synthase (eNOS), it is demonstrated that eNOS in hippocampal pyramidal cells may generate the NO that has been postulated as a retrograde messenger of long-term potentiation.
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Back in the water: the return of the inositol phosphates
TL;DR: Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.
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Testosterone and Dihydrotestosterone Tissue Levels in Recurrent Prostate Cancer
Mark Titus,Michael J. Schell,Fred B. Lih,Kenneth B. Tomer,James L. Mohler,James L. Mohler,James L. Mohler +6 more
TL;DR: Recurrent prostate cancer may develop the capacity to biosynthesize testicular androgens from adrenal androgens or cholesterol, a surprising finding that suggests intracrine production of dihydrotestosterone should be exploited for novel treatment of recurrent prostate cancer.
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d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors
TL;DR: Compared the immunohistochemical localizations of d-serine, glycine, and NMDA receptors in rat brain, d-Serine seems to be the endogenous ligand of glycine sites in the telencephalon and developing cerebellum, whereas glycine predominates in the adult cere Bellum, olfactory bulb, and hindbrain.