D
Derek C. Radisky
Researcher at Mayo Clinic
Publications - 222
Citations - 17001
Derek C. Radisky is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 64, co-authored 196 publications receiving 15265 citations. Previous affiliations of Derek C. Radisky include University of California, Berkeley & Lawrence Berkeley National Laboratory.
Papers
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Journal ArticleDOI
Putting tumours in context
Mina J. Bissell,Derek C. Radisky +1 more
TL;DR: In this article, the interactions between cancer cells and their micro-and macro-environment create a context that promotes tumour growth and protects it from immune attack, and the functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses.
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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
Derek C. Radisky,Dinah Levy,Laurie E. Littlepage,Hong Liu,Celeste M. Nelson,Jimmie E. Fata,Devin Leake,Elizabeth L. Godden,Donna G. Albertson,M. Angela Nieto,Zena Werb,Mina J. Bissell +11 more
TL;DR: These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation.
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The organizing principle: microenvironmental influences in the normal and malignant breast.
TL;DR: A considerable body of evidence now shows that cell-cell and cell-extracellular matrix (ECM) interactions are essential organizing principles that help define the nature of the tissue context, and play a crucial role in regulating homeostasis and tissue specificity.
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Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer
TL;DR: Recent studies showing how M MPs activate EMT in mammary gland development and in breast cancer, and how MMPs mediate breast cancer cell motility, invasion, and EMT-driven breast cancer progression are summarized are summarized and approaches to inhibit these MMP-mediated malignant processes are suggested.
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Epithelial-mesenchymal transition
TL;DR: The epithelial-mesenchymal transition (EMT) is an orchestrated series of events in which cell-cell and cell-extracellular matrix (ECM) interactions are altered to release epithelial cells from the surrounding tissue and the cytoskeleton is reorganized to confer the ability to move through a three-dimensional environment.