M
Michael Keoni Manion
Researcher at Wilmington University
Publications - 39
Citations - 625
Michael Keoni Manion is an academic researcher from Wilmington University. The author has contributed to research in topics: Cytotoxic T cell & Generator (computer programming). The author has an hindex of 9, co-authored 39 publications receiving 609 citations. Previous affiliations of Michael Keoni Manion include Fred Hutchinson Cancer Research Center.
Papers
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Journal ArticleDOI
A novel approach for monitoring extracellular acidification rates: based on bead injection spectrophotometry and the lab-on-valve system.
TL;DR: In this paper, the authors presented a method that exploits an immobilized pH indicator on the surface of microcarrier beads (Sephadex®) and is probed with a fiber optic coupled spectrophotometer.
Journal Article
Small-molecule inhibitors of Bcl-2.
TL;DR: Two Bcl-2 small-molecule inhibitors are currently undergoing phase I/II clinical trials and several other compounds are in preclinical development, and ongoing studies with these investigational drugs should provide new insights into optimal strategies to disrupt B cl-2 survival functions to selectively kill cancer cells.
Journal ArticleDOI
Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma
Robert Ten Broeke,Gert Folkerts,Thea Leusink-Muis,Henk J. van der Linde,Matteo Villain,Michael Keoni Manion,Fred De Clerck,J. Edwin Blalock,Frans P. Nijkamp +8 more
TL;DR: It is concluded that epithelial calcium channels play a key role in regulating airway hyperresponsiveness by controlling [Ca2+]i and consequently the production of NO, and suggest new therapeutic targets for asthma.
Patent
Spatial heat treatment of additively manufactured objects
TL;DR: In this article, a matrix material dispersed with one or more susceptor structures can be formed into a feedstock for an additive manufacturing process, and the heat that is produced can be transferred to the matrix material that surrounds the susceptor structure to provide heat treatment.
Patent
Proprioceptive endoscope and virtual dynamic tomography
TL;DR: In this article, the authors describe a device for endoscopy that includes a first segment of endoscopic tube, a second segment, and at least one positional sensor configured to determine a relative orientation of the first segment to the second segment.