M
Michael Kovochich
Researcher at University of California, Los Angeles
Publications - 33
Citations - 9479
Michael Kovochich is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Particle size & Oxidative stress. The author has an hindex of 17, co-authored 32 publications receiving 8678 citations. Previous affiliations of Michael Kovochich include University of Southern California.
Papers
More filters
Journal ArticleDOI
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.
Tian Xia,Michael Kovochich,Monty Liong,Lutz Mädler,Lutz Mädler,Benjamin Gilbert,Haibin Shi,Joanne I. Yeh,Jeffrey I. Zink,Andre E. Nel +9 more
TL;DR: The results demonstrate that metal oxide nanoparticles induce a range of biological responses that vary from cytotoxic to cytoprotective and can only be properly understood by using a tiered test strategy such as that developed for oxidative stress and adapted to study other aspects of nanoparticle toxicity.
Journal ArticleDOI
Comparison of the Abilities of Ambient and Manufactured Nanoparticles To Induce Cellular Toxicity According to an Oxidative Stress Paradigm
Tian Xia,Michael Kovochich,Jonathan A. Brant,Matt Hotze,Joan M. Sempf,Terry Oberley,Constantinos Sioutas,Joanne I. Yeh,Mark R. Wiesner,Andre E. Nel +9 more
TL;DR: It is demonstrated that ROS generation and oxidative stress are a valid test paradigm to compare NP toxicity, and particle interactions with cellular components are capable of generating oxidative stress.
Journal ArticleDOI
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Monty Liong,Jie Lu,Michael Kovochich,Tian Xia,Stefan G. Ruehm,Andre E. Nel,Fuyuhiko Tamanoi,Jeffrey I. Zink +7 more
TL;DR: In this article, superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation.
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug
Delivery Liong,Jie Lu,Michael Kovochich,Tian Xia,Stefan G. Ruehm,Andre E. Nel,Fuyuhiko Tamanoi,Jeffrey I. Zink +7 more
TL;DR: Water-insoluble anticancer drugs were delivered into human cancer cells; surface conjugation with cancer-specific targeting agents increased the uptake into cancer cells relative to that in non-cancerous fibroblasts.
Journal ArticleDOI
Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs
Tian Xia,Michael Kovochich,Monty Liong,Huan Meng,Sanaz Kabehie,Saji George,Jeffrey I. Zink,Andre E. Nel +7 more
TL;DR: It is demonstrated that, by a careful selection of PEI size, it is possible to construct cationic MSNP that are capable of nucleotide and enhanced drug delivery with minimal or no cytotoxicity.