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Michael Kovochich
Researcher at University of California, Los Angeles
Publications - 33
Citations - 9479
Michael Kovochich is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Particle size & Oxidative stress. The author has an hindex of 17, co-authored 32 publications receiving 8678 citations. Previous affiliations of Michael Kovochich include University of Southern California.
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Journal ArticleDOI
Activation of Latent HIV Using Drug-Loaded Nanoparticles
TL;DR: The development of a novel lipid nanoparticle with the protein kinase C activator bryostatin-2 incorporated (LNP-Bry) that can target and activate primary human CD4+ T-cells and stimulate latent virus production from human T-cell lines in vitro and from latently infected cells in a humanized mouse model ex vivo is described.
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Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants Part I: Physicochemical properties in patient and simulator studies
Amy K. Madl,Monty Liong,Michael Kovochich,Brent L. Finley,Dennis J. Paustenbach,Günter Oberdörster +5 more
TL;DR: This two-part review attempted to identify and critically evaluate the relevant physicochemical characteristics of CoCr wear particles from hip implant patients and simulator systems and evaluated in vitro and animal toxicology studies with respect to the physicochemistry and dose-relevance to metal-on-metal implant patients.
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Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition.
Michael Kovochich,Benjamin Espinasse,Mélanie Auffan,Ernest M. Hotze,Lauren E. Wessel,Tian Xia,Andre E. Nel,Mark R. Wiesner +7 more
TL;DR: The results demonstrate that THF/nC60 but not fullerol or aqueous nC60 generates cellular toxicity through a pathway that involves increased intracellular flux and mitochondrial perturbation in RAW 264.7 cells.
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Chemical mapping of tire and road wear particles for single particle analysis.
Michael Kovochich,Monty Liong,Jillian A. Parker,Su Cheun Oh,Jessica P. Lee,Luan Xi,Marisa L. Kreider,Kenneth M. Unice +7 more
TL;DR: Comparisons of TRWP with other polymeric (polystyrene) and non-polymeric (carbon black) particle types demonstrated that a combination of physical and chemical markers is necessary to identify TRWP.
Journal ArticleDOI
Understanding outcomes and toxicological aspects of second generation metal-on-metal hip implants: a state-of-the-art review.
Michael Kovochich,Brent L. Finley,Rachel M Novick,Andrew D. Monnot,Ellen P. Donovan,Kenneth M. Unice,Ernest S. Fung,David Fung,Dennis J. Paustenbach +8 more
TL;DR: While toxicological assessments of normal functioning MoM hip implants indicate that MoM implants are relatively safe because of low wear and clearance of metal, more analysis of revision data is needed in order to best inform patient management decisions, particularly for asymptomatic patients.