Showing papers in "Nanomedicine: Nanotechnology, Biology and Medicine in 2015"

TL;DR: A comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug Delivery systems.

TL;DR: A systematic comparison between two protocols for EV purification: ultrafiltration with subsequent liquid chromatography (UF-LC) and differential ultracentrifugation (UC) for EV recovery shows that UF-LC is scalable and adaptable for EV isolation from complex media types such as stem cell media, which is of huge significance for future clinical applications involving EVs.

TL;DR: An overview of the current state of research in utilizing gold nanomaterials for PA imaging of cancer, atherosclerotic plaques, brain function and image-guided therapy is provided.

TL;DR: The authors described and discussed the various approaches current nano-delivery systems can offer in overcoming the limitations of conventional drug formulations and the future advances of this research are discussed.

TL;DR: In this article, the authors synthesized and characterized curcumin nanoparticles (curc-np), which inhibited in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in dose-dependent fashion.

TL;DR: The current status of drug delivery to the CNS is described, based on particle size and shape, and the importance of size, surface charge, and shape of nanoparticles in determining therapeutic effects on brain and retinal diseases is highlighted.

TL;DR: The authors studied the biological effects of spherical SNPs with precise diameters between 20 and 200 nm on three different cell types and their results should provide more data on safety for better drug design.

TL;DR: The results indicate that assessment of genotoxicity and gene expression add information on toxicity of nanocarriers, which is not obtained by histology and hematology, as well as its effects on the lungs, spleen and liver.

TL;DR: The current state of knowledge for AuNP x-ray contrast agents within a paradigm of key structure-property-function relationships is summarized to provide guidance for the design of AuNP contrast agents to meet the necessary functional requirements in a particular application.

TL;DR: This comprehensive review presents an overview of DDSs to release GFs for skin regeneration, particularly emphasising on polymeric micro and nanospheres, lipid nanoparticles, nanofibrous structures, hydrogels and scaffolds.

TL;DR: It is proposed that endocytosed AgNPs are degraded in the lysosomes and the release of Ag(+) ions in the cytosol induces cell damages, while ions released in the cell culture medium play a negligible effect, and will be useful to develop safer-by-design nanoparticles and proper regulatory guidelines of AgNPS.

TL;DR: An in-depth review on various nanoparticle platforms in cancer therapeutics is performed and options to improve drug delivery, in terms of carrier design are suggested.

TL;DR: Factors that affect nanobodies performance at three different stages: their systemic circulation upon intravenous injection; their extravasation and tumor penetration; and, finally, their interaction with target molecules.

TL;DR: This review will focus on the emerging field of liposome-protein corona research from basic, descriptive research to readily applicable knowledge and technologies for implementation in drug improvement and development.

TL;DR: A comprehensive review on current research in nanoparticle-based therapies for bone tissue engineering is provided, which should be useful reading for clinicians as well as researchers in this field.

TL;DR: The effects of particle size and shape on in vivo behavior of mesoporous silica nanoparticles are evaluated to shine light on future design of future drug delivery systems and bring new insights into nanotoxicity.

TL;DR: Although still in the early stages of development, ideal photothermal therapy (PTT) refers to treating cancer by targeted delivery of biocompatible photothermal nanoparticles and heat to the site of interest without damaging the surrounding healthy tissue.

TL;DR: In this concise review, the author described and discussed the current unresolved issues over the application of inorganic nanoparticles for medical applications.

TL;DR: In this article, the authors used goserelin-conjugated gold nanorods for radiosensitization of prostate cancers in vitro and in vivo, and showed that the high concentrations of gold required, the long interval between injection of nanoparticles and radiation, and the use of megavoltage radiation to generate radiosenseitization in vivo foretell the possibility of eventual clinical translation of this approach.

TL;DR: All aspects of how graphene is internalized after in vivo administration or in vitro cell exposure were brought about, and how blood-brain barrier can be overlapped by graphene nanomaterials are explained.

TL;DR: This comprehensive review describes and discusses the current status, drug design and modification for targeted delivery and challenges of the use of nanoparticles in the respiratory tract.

TL;DR: A novel application is demonstrated in that these nanoparticles were efficient in promoting osteoblastic differentiation in both in-vitro and in- vivo studies, which may provide a new treatment direction for bone fracture in the future.

TL;DR: The relentless advance of drug-resistance among pathogenic microbes, mandates a search for alternative approaches that will not cause resistance, and this review will cover photocatalytic disinfection with titania nanoparticles, carbon nanomaterials, Carbon nanotubes and graphene, liposomes and polymeric nanoparticles.

TL;DR: The synthesis of folate (FA)-conjugated selenium nanoparticles (SeNPs) as cancer-targeted nano-drug delivery system for ruthenium polypyridyl (RuPOP) exhibits strong fluorescence, which allows the direct imaging of the cellular trafficking of the nanosystem.

TL;DR: The recent progress in advanced therapy for cutaneous wound healing during last 5 years using a nanotechnology-based approach is summarized.

TL;DR: By combining nanoparticles of silver/QAM/NACP, a new class of composites and adhesives with antibacterial and remineralization double benefits was developed and has potential to significantly improve restorative and preventive dentistry.

TL;DR: A facile and efficient strategy has successfully been introduced that can produce 3D silk fibroin nanofibers, obviating an intrinsic limitation of traditional and salt-leaching electrospinning by introducing cold-plate electrosp spinning.

TL;DR: The authors undertook the first clinical trial using long-circulating liposomal nanoparticle encapsulating prednisolone in patients with atherosclerosis, based on previous animal studies, and successfully delivered a long- circulating nanoparticle to atherosclerotic plaque macrophages in patients.

TL;DR: In vivo study in MCF-7 tumor-bearing mice demonstrated that the AS1411-functionalized composite micelles showed prolonged circulation time in blood, enhanced accumulation in tumor, improved antitumor activity, and decreased cardiotoxicity, suggesting that aptamer-conjugated multifunctional composite miceLLes could be a potential delivery vehicle for cancer therapy.

TL;DR: It was shown that the microvesicles could be manipulated by magnetic force for targeting and subsequent delivery of the drug payload against cancer cells and that cancer cell death was enhanced by the magnetic targeting.