M
Michael L. Johnson
Researcher at University of Virginia
Publications - 293
Citations - 18048
Michael L. Johnson is an academic researcher from University of Virginia. The author has contributed to research in topics: Luteinizing hormone & Quenching (fluorescence). The author has an hindex of 66, co-authored 276 publications receiving 17595 citations. Previous affiliations of Michael L. Johnson include National Science Foundation & University of California, San Diego.
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Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection
TL;DR: This work has formulated a computerized algorithm in which a pulse is defined as a statistically significant increase in a "cluster" of hormone values followed by a statisticallysignificant decrease in a second cluster of values.
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Analysis of data from the analytical ultracentrifuge by nonlinear least-squares techniques.
TL;DR: Least-squares analysis of experimental data from the analytical ultracentrifuge is discussed in detail, with particular attention to the use of interference optics in studying nonideal self-associating macromolecular systems.
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Fluorescence lifetime imaging of free and protein-bound NADH.
TL;DR: FLIM is used to create lifetime images of NADH when free in solution and when bound to malate dehydrogenase, and describes am imaging procedure that allows specific decay times to be suppressed, allowing in this case suppression of the emission from either free or bound NADH.
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The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations
TL;DR: Observed physiological patterns of fluctuating plasma hormone concentrations can be accounted for by distinct, highly delimited, random bursts of hormone release separated by intervals of secretory quiescence.
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Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man.
Johannes D. Veldhuis,Ali Iranmanesh,Ken K. Y. Ho,Michael J. Waters,Michael L. Johnson,German Lizarralde +5 more
TL;DR: It is concluded that obese men harbor a double defect in GH dynamics involving both GH secretion and clearance, and that the severity of the GH secretory deficiency is proportionate to the degree of obesity.