Michael Markert

TL;DR: The anaesthesias influenced very differently the cardiovascular parameters measured in Wistar rats, and the long wake-up and recovery period suggest the need for prolonged monitoring.

TL;DR: The aspects for developing a strategy for the preclinical testing of drug candidates for proarrhythmic potential are presented and the validation of such a strategy and its utility in drug development is now well established and recommended, independent from future regulatory requirements.

TL;DR: It is concluded that ECG data from toxicological studies can offer complementary ECGs data that can strengthen a risk assessment, but for the great majority of standard toxicity studies conducted, the ECGs collected do not permit an adequate assessment of drug-induced effects on the QT interval with the sensitivity expected from the ICH S7B guidelines.

TL;DR: These are the first data documenting the course of systemic arterial and ventricular hemodynamic parameters in the freely moving Göttingen Minipig over 24 h, and may serve as a basis for future studies in which drug effects are studied in these animals.

TL;DR: This study demonstrated that the quality of the acquired cardiovascular data for conscious dogs is dependent on the pen configuration and group make-up during a study.