N
Norbert Weissmann
Researcher at University of Giessen
Publications - 423
Citations - 24136
Norbert Weissmann is an academic researcher from University of Giessen. The author has contributed to research in topics: Pulmonary hypertension & Hypoxia (medical). The author has an hindex of 71, co-authored 384 publications receiving 21187 citations. Previous affiliations of Norbert Weissmann include German Red Cross & Imperial College London.
Papers
More filters
Journal ArticleDOI
Reversal of experimental pulmonary hypertension by PDGF inhibition.
Ralph T. Schermuly,Eva Dony,Hossein Ardeschir Ghofrani,Soni Savai Pullamsetti,Rajkumar Savai,Markus Roth,Akylbek Sydykov,Ying Ju Lai,Norbert Weissmann,Werner Seeger,Friedrich Grimminger +10 more
TL;DR: STI571 reverses vascular remodeling and cor pulmonale in severe experimental pulmonary hypertension regardless of the initiating stimulus, and offers a unique novel approach for antire-modeling therapy in progressed pulmonary hypertension.
Journal ArticleDOI
Cellular and molecular basis of pulmonary arterial hypertension.
Nicholas W. Morrell,Serge Adnot,Stephen L. Archer,Jocelyn Dupuis,Peter L. Jones,Margaret R. MacLean,Ivan F. McMurtry,Kurt R. Stenmark,Patricia A. Thistlethwaite,Norbert Weissmann,Jason X.-J. Yuan,E. Kenneth Weir +11 more
TL;DR: The origins of a cell type critical to the process of pulmonary vascular remodeling, the myofibroblast, are discussed, and the evidence supporting a contribution for the involvement of endothelial-mesenchymal transition and recruitment of circulating mesenchymic progenitor cells is reviewed.
Journal ArticleDOI
Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial
Hossein Ardeschir Ghofrani,Ralph Wiedemann,Frank Rose,Ralph T. Schermuly,Horst Olschewski,Norbert Weissmann,Andreas Günther,Dieter Walmrath,Werner Seeger,Friedrich Grimminger +9 more
TL;DR: Sildenafil causes preferential pulmonary vasodilation and improves gas exchange in patients with severe lung fibrosis and secondary pulmonary hypertension, and ratio of pulmonary to systemic vascular resistance decreased only in individuals who received nitric oxide and sildanafil.
Journal ArticleDOI
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.
TL;DR: It is confirmed that ONOO– uncouples eNOS by oxidation of tetrahydrobiopterin and that ascorbate does not fully protect BH4 from oxidation but recycles its radical, and that the BH 4 reaction rate constant exceeds those of thiols or asCorbate.
Journal ArticleDOI
Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase
Katrin Schröder,Min Zhang,Sebastian Benkhoff,Anja Mieth,Rainer U. Pliquett,Judith Kosowski,Christoph Kruse,Peter Luedike,U. Ruth Michaelis,Norbert Weissmann,Stefanie Dimmeler,Ajay M. Shah,Ralf P. Brandes +12 more
TL;DR: Endogenous Nox4 protects the vasculature during ischemic or inflammatory stress and may have a protective vascular function, different from Nox1 and Nox2.