We present here the first update of the 2013 EFSUMB (European Federation of Societies for Ultrasound in Medicine and Biology) Guidelines and Recommendations on the clinical use of elastography with a focus on the assessment of diffuse liver disease. The short version provides clinical information about the practical use of elastography equipment and interpretation of results in the assessment of diffuse liver disease and analyzes the main findings based on published studies, stressing the evidence from meta-analyses. The role of elastography in different etiologies of liver disease and in several clinical scenarios is also discussed. All of the recommendations are judged with regard to their evidence-based strength according to the Oxford Centre for Evidence-Based Medicine Levels of Evidence. This updated document is intended to act as a reference and to provide a practical guide for both beginners and advanced clinical users.

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EFSUMB Guidelines and Recommendations on the Clinical Use of Liver Ultrasound Elastography, Update 2017 (Long Version)

The gut-liver axis in liver disease: Pathophysiological basis for therapy.

BACKGROUND In 2013, New York began requiring hospitals to follow protocols for the early identification and treatment of sepsis. However, there is controversy about whether more rapid treatment of sepsis improves outcomes in patients. METHODS We studied data from patients with sepsis and septic shock that were reported to the New York State Department of Health from April 1, 2014, to June 30, 2016. Patients had a sepsis protocol initiated within 6 hours after arrival in the emergency department and had all items in a 3‐hour bundle of care for patients with sepsis (i.e., blood cultures, broad‐spectrum antibiotic agents, and lactate measurement) completed within 12 hours. Multilevel models were used to assess the associations between the time until completion of the 3‐hour bundle and risk‐adjusted mortality. We also examined the times to the administration of antibiotics and to the completion of an initial bolus of intravenous fluid. RESULTS Among 49,331 patients at 149 hospitals, 40,696 (82.5%) had the 3‐hour bundle completed within 3 hours. The median time to completion of the 3‐hour bundle was 1.30 hours (interquartile range, 0.65 to 2.35), the median time to the administration of antibiotics was 0.95 hours (interquartile range, 0.35 to 1.95), and the median time to completion of the fluid bolus was 2.56 hours (interquartile range, 1.33 to 4.20). Among patients who had the 3‐hour bundle completed within 12 hours, a longer time to the completion of the bundle was associated with higher risk‐adjusted in‐hospital mortality (odds ratio, 1.04 per hour; 95% confidence interval [CI], 1.02 to 1.05; P<0.001), as was a longer time to the administration of antibiotics (odds ratio, 1.04 per hour; 95% CI, 1.03 to 1.06; P<0.001) but not a longer time to the completion of a bolus of intravenous fluids (odds ratio, 1.01 per hour; 95% CI, 0.99 to 1.02; P=0.21). CONCLUSIONS More rapid completion of a 3‐hour bundle of sepsis care and rapid administration of antibiotics, but not rapid completion of an initial bolus of intravenous fluids, were associated with lower risk‐adjusted in‐hospital mortality. (Funded by the National Institutes of Health and others.)

Supplement to: Time to treatment and mortality during mandated emergency care for sepsis.

Enoxaparin Prevents Portal Vein Thrombosisand Liver Decompensation in Patients With Advanced Cirrhosis.

Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2 diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these disorders are characterized by alterations in the intestinal microbiota composition and its metabolites, which translocate from the gut across a disrupted intestinal barrier to affect various metabolic organs, such as the liver and adipose tissue, thereby contributing to metabolic inflammation. Here, we discuss some of the recently identified mechanisms that showcase the role of the intestinal microbiota and barrier dysfunction in metabolic inflammation. We propose a concept by which the gut microbiota fuels metabolic inflammation and dysregulation. Here, the authors describe how metabolic disorders, such as type 2 diabetes and nonalcoholic fatty liver disease, are driven by alterations in the composition of the intestinal microbiota and its metabolites, which translocate from the gut across a disrupted intestinal barrier and contribute to metabolic inflammation.

The intestinal microbiota fuelling metabolic inflammation

Closing spontaneous portosystemic shunts in cirrhosis: Does it make sense? Does it work? What does it take?

Background and Aims The prevalence of coronary artery disease (CAD) in patients with liver cirrhosis is high. The risk of developing cardiovascular disease (CVD) events in patients with cirrhosis and known CAD has not been evaluated yet. Thus, the aim of this study was to evaluate the risk of CVD events and associated predictors in patients with cirrhosis and CAD. 

Decompensation Increases The Risk of Cardiovascular Events In
 Patients With Cirrhosis and Coronary Artery Disease

Neuromyelitis optica (NMO) or Devics syndrome is an inflammatory, demyelinating disease of the central nervous system leading to optical neuritis and myelitis Etiology of NMO is unknown, although autoimmune disorders involving IgG autoantibodies specific for aquaporin 4 are suspected These autoantibodies are associated with 73% sensitivity 93% specificity for NMO helping to distinguish NMO from other demyelinating disorders Some cases of NMO are reported in association with systemic lupus erythematosus and Sjogrens syndrome Here we report a patient presenting with NMO and concomitantly occurring rapid progressive crescentic intra- and extracapillary crescentic glomerulonephritis

Crescentic glomerulonephritis in a patient with neuromyelitis optica (Devics syndrom)

Comorbidities and complications of patients hospitalized for liver transplantation evaluation, transplant and post-LT: a fourteen-year nationwide study in Germany

Zielsetzung Die Schweregradabschätzung der Leberzirrhose ist für das Patientenmanagement und die Prognoseabschätzung wichtig. Die Leber-MRT mit Mapping des extrazellulären Volumens (EZV) eignet sich möglicherweise zur Differenzierung unterschiedlicher Child-Pugh Stadien bei Leberzirrhose. 

Michael Praktiknjo

Papers

Closing spontaneous portosystemic shunts in cirrhosis: Does it make sense? Does it work? What does it take?

Decompensation Increases The Risk of Cardiovascular Events In Patients With Cirrhosis and Coronary Artery Disease

Crescentic glomerulonephritis in a patient with neuromyelitis optica (Devics syndrom)

Comorbidities and complications of patients hospitalized for liver transplantation evaluation, transplant and post-LT: a fourteen-year nationwide study in Germany

Bestimmung des Schweregrads der Leberzirrhose in der Leber-MRT mittels Mapping des extrazellulären Volumens