Michael R. Bösl

TL;DR: It is found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindin-2 is required for talin-induced integrin activation, and it is demonstrated that Kindlins-2 are required for integrin outside-in signaling to enable firm adhesion and spreading.

TL;DR: It is shown that at standard NaCl intake, renal water and electrolyte excretion is indistinguishable in sgk1-knockout mice and wild-type (sgk1(+/+)) mice, and dietary NaCl restriction reveals an impaired ability of sgK1(-/-) mice to adequately decrease Na(+) excretion despite increases in plasma aldosterone levels and proximal-tubular Na(+) and fluid reabsorption.

TL;DR: In slice preparations of the spinal cord, no difference between the functional properties of EGFP‐positive and negative neurons could be detected, confirming the utility of visually identifying glycinergic neurons to investigate their functional role in electrophysiological studies.

TL;DR: These findings empirically confirm that standardized experiments can generate spurious results by increasing test sensitivity at the expense of external validity and have important implications for behavioral screening studies but may also apply to other areas of laboratory research that are fraught with poor reproducibility because of study-, site and sample-specific idiosyncrasies.

TL;DR: These results establish glycinergic neurons of the spinal dorsal horn as key elements of an inhibitory pain and itch control circuit.