M
Michael Sixt
Researcher at Institute of Science and Technology Austria
Publications - 153
Citations - 15720
Michael Sixt is an academic researcher from Institute of Science and Technology Austria. The author has contributed to research in topics: Integrin & Cell migration. The author has an hindex of 55, co-authored 144 publications receiving 13323 citations. Previous affiliations of Michael Sixt include University of Erlangen-Nuremberg & Max Planck Society.
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Journal ArticleDOI
Lifeact: a versatile marker to visualize F-actin
Julia Riedl,Alvaro H. Crevenna,Kai Kessenbrock,Jerry Haochen Yu,Dorothee Neukirchen,Michal Bista,Frank Bradke,Dieter E. Jenne,Tad A. Holak,Zena Werb,Michael Sixt,Roland Wedlich-Söldner +11 more
TL;DR: Lifeact, a 17-amino-acid peptide, is described, which stained filamentous actin (F-actin) structures in eukaryotic cells and tissues and in its chemically modified peptide form allowed visualization of actin dynamics in nontransfectable cells.
Journal ArticleDOI
Rapid leukocyte migration by integrin-independent flowing and squeezing
Tim Lämmermann,Bernhard L. Bader,Susan J. Monkley,Tim Worbs,Roland Wedlich-Söldner,Karin Hirsch,Markus Keller,Reinhold Förster,David R. Critchley,Reinhard Fässler,Michael Sixt +10 more
TL;DR: It is shown here that functional integrins do not contribute to migration in three-dimensional environments, and these cells migrate by the sole force of actin-network expansion, which promotes protrusive flowing of the leading edge.
Journal ArticleDOI
The Conduit System Transports Soluble Antigens from the Afferent Lymph to Resident Dendritic Cells in the T Cell Area of the Lymph Node
Michael Sixt,Nobuo Kanazawa,Manuel Selg,Thomas Samson,Gunnel Roos,Dieter P. Reinhardt,Reinhard Pabst,Manfred B. Lutz,Lydia Sorokin +8 more
TL;DR: Using high-resolution light microscopy and 3D reconstruction, it is shown here that these conduits are unique basement membrane-like structures ensheathed by fibroblastic reticular cells with occasional resident DC embedded within this cell layer.
Journal ArticleDOI
Mechanical modes of 'amoeboid' cell migration.
Tim Lämmermann,Michael Sixt +1 more
TL;DR: It is argued that shifting the balance between actin protrusion, actomyosin contraction, and adhesion to the extracellular substrate can explain the different modes of amoeboid movement and that blebbing and gliding are barely extreme variants of one common migration strategy.
Journal ArticleDOI
Breaching multiple barriers : Leukocyte motility through venular walls and the interstitium
TL;DR: Emerging cellular models are now addressing the transition from an adherent mode to a non-adherent state, incorporating mechanisms that support an efficient migratory profile of leukocytes in the interstitial tissue beyond the venular wall.