Michael S. Lidow

TL;DR: The different regional and laminar distributions of D1 and D2 dopaminergic receptors indicates that they may subserve different aspects of dopamine function in the cerebral cortex.

TL;DR: The synchronized development of neurotransmitter receptors in diverse layers and regions of the neocortex occurs pari passu with synaptogenesis, demonstrating unusual coordination of biochemical and structural maturation and supporting the hypothesis that the entire cerebral cortex matures as an integrated network, rather than as a system-by-system cascade.

TL;DR: Evidence supporting the cerebral cortex as a pivotal site for these mechanisms underlying the action of antipsychotics and balancing the opposing actions of dopamine D1 and D2 receptor regulation may hold the key to optimal drug therapy and to understanding the pathophysiology of schizophrenia.

TL;DR: The present study establishes the presence and widespread distribution of dopamine D2 receptors in the cortex of rat and monkey using the D2 selective antagonist [3H]raclopride.

TL;DR: These parameters in a rat model of short‐lasting (∼24 h) neonatal local inflammation of a hindpaw produced by injection of 0.25% carrageenan provide a framework within which the entire complex of long‐term effects of early noxious experience can be understood and examined.