M
Michael Schaefer
Researcher at Leipzig University
Publications - 81
Citations - 2190
Michael Schaefer is an academic researcher from Leipzig University. The author has contributed to research in topics: Transient receptor potential channel & Receptor. The author has an hindex of 21, co-authored 70 publications receiving 1675 citations. Previous affiliations of Michael Schaefer include St. Michael's Hospital.
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Journal ArticleDOI
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.
Manuela Rossol,Matthias Pierer,Nora Raulien,Dagmar Quandt,Undine Meusch,Kathrin Rothe,Kristin Schubert,Torsten Schöneberg,Michael Schaefer,Ute Krügel,Sanela Smajilovic,Hans Bräuner-Osborne,Christoph Baerwald,Ulf Wagner +13 more
TL;DR: The results demonstrate that G-protein-coupled receptors can activate the inflammasome, and indicate that increased extracellular calcium has a role as a danger signal and amplifier of inflammation.
Journal ArticleDOI
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
Cheng-Chang Chen,Marco Keller,Martin Hess,Raphael Schiffmann,Nicole Urban,Annette Wolfgardt,Michael Schaefer,Franz Bracher,Martin Biel,Christian Wahl-Schott,Christian Grimm +10 more
TL;DR: It is found that activation of MLIV mutant isoforms by the endogenous ligand PI(3,5)P2 is strongly reduced, while activity can be increased using synthetic ligands.
Journal ArticleDOI
Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors.
Wolfgang Nörenberg,Helga Sobottka,Christoph Hempel,T Plötz,Wolfgang Fischer,Günther Schmalzing,Michael Schaefer +6 more
TL;DR: Evidence is provided that the reported isoform selectivity of ivermectin is a species‐specific phenomenon.
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Flavanones that Selectively Inhibit TRPM3 Attenuate Thermal Nociception In Vivo
Isabelle Straub,Ute Krügel,Florian Mohr,Jens Teichert,Oleksandr Rizun,Maik Konrad,Johannes Oberwinkler,Michael Schaefer +7 more
TL;DR: Isosakuranetin and previously identified hesperetin significantly reduced the sensitivity of mice to noxious heat and PregS-induced chemical pain and are to the authors' knowledge the most potent inhibitor of TRPM3 identified so far.
Journal ArticleDOI
Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3.
Isabelle Straub,Florian Mohr,J Stab,Maik Konrad,Stephan E. Philipp,Johannes Oberwinkler,Michael Schaefer +6 more
TL;DR: The melastatin‐related transient receptor potential TRPM3 is a calcium‐permeable nonselective cation channel that can be activated by the neurosteroid pregnenolone sulphate (PregS) and heat and drugs inhibiting it possibly get in focus of analgesic therapy.