C
Cheng-Chang Chen
Researcher at Ludwig Maximilian University of Munich
Publications - 33
Citations - 1732
Cheng-Chang Chen is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Ion channel & Medicine. The author has an hindex of 15, co-authored 26 publications receiving 1160 citations. Previous affiliations of Cheng-Chang Chen include Center for Integrated Protein Science Munich & National Taiwan University.
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Journal ArticleDOI
Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
Yasuteru Sakurai,Andrey A. Kolokoltsov,Cheng-Chang Chen,Michael W. Tidwell,William E. Bauta,Norbert Klugbauer,Christian Grimm,Christian Wahl-Schott,Martin Biel,Robert A. Davey +9 more
TL;DR: It is found that Ebola virus entry into host cells requires the endosomal calcium channels called two-pore channels called TPCs, and disrupting TPC function by gene knockout, small interfering RNAs, or small-molecule inhibitors halted virus trafficking and prevented infection.
Journal ArticleDOI
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice
Christian Grimm,Lesca M. Holdt,Cheng-Chang Chen,Sami Hassan,Christoph Müller,Simone Jörs,Hartmut Cuny,Sandra Kissing,Bernd Schröder,Elisabeth Butz,Bernd H. Northoff,Jan Castonguay,Christian A. Luber,Markus Moser,Saskia Spahn,Renate Lüllmann-Rauch,Christina Fendel,Norbert Klugbauer,Oliver Griesbeck,Albert Haas,Matthias Mann,Franz Bracher,Daniel Teupser,Paul Saftig,Martin Biel,Christian Wahl-Schott +25 more
TL;DR: The results suggest that TPC2 plays a crucial role in trafficking in the endolysosomal degradation pathway and, thus, is potentially involved in the homoeostatic control of many macromolecules and cell metabolites.
Journal ArticleDOI
Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells
Margarida Ruas,Lianne C. Davis,Cheng-Chang Chen,Anthony J. Morgan,Kai Ting Chuang,Timothy F. Walseth,Christian Grimm,Clive Garnham,Trevor Powell,Nick Platt,Frances M. Platt,Martin Biel,Christian Wahl-Schott,John Parrington,Antony Galione +14 more
TL;DR: TPCs are established as Ca2+‐permeable channels indispensable for NAADP signalling, and high‐affinityNAADP binding still occurs in Tpcn1/2−/− tissue, suggesting that NAadP regulation is conferred by an accessory protein.
Journal ArticleDOI
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
Cheng-Chang Chen,Marco Keller,Martin Hess,Raphael Schiffmann,Nicole Urban,Annette Wolfgardt,Michael Schaefer,Franz Bracher,Martin Biel,Christian Wahl-Schott,Christian Grimm +10 more
TL;DR: It is found that activation of MLIV mutant isoforms by the endogenous ligand PI(3,5)P2 is strongly reduced, while activity can be increased using synthetic ligands.
Journal ArticleDOI
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Susanne Gerndt,Cheng-Chang Chen,Yu-Kai Chao,Yu Yuan,Sandra Burgstaller,Anna Scotto Rosato,Einar Krogsaeter,Nicole Urban,Katharina Jacob,Ong Nam Phuong Nguyen,Meghan T. Miller,Meghan T. Miller,Marco Keller,Angelika M. Vollmar,Thomas Gudermann,Susanna Zierler,Johann Schredelseker,Michael Schaefer,Michael Schaefer,Martin Biel,Roland Malli,Christian Wahl-Schott,Franz Bracher,Sandip Patel,Christian Grimm +24 more
TL;DR: It is shown that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated, depends on the activating ligand, and a new paradigm is established whereby a single ion channel mediates distinct, functionally-relevant ionic signatures on demand.