M
Michael Scher
Researcher at University of Medicine and Dentistry of New Jersey
Publications - 8
Citations - 2721
Michael Scher is an academic researcher from University of Medicine and Dentistry of New Jersey. The author has contributed to research in topics: Histone code & Histone H1. The author has an hindex of 7, co-authored 7 publications receiving 2495 citations. Previous affiliations of Michael Scher include New York University & Rutgers University.
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Journal ArticleDOI
Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin
Alejandro Vaquero,Michael Scher,Donghoon Lee,Hediye Erdjument-Bromage,Paul Tempst,Danny Reinberg +5 more
TL;DR: A model for SirT1-mediated heterochromatin formation is proposed that includes deacetylation of histone tails, recruitment and deacetolation of Histone H1, and spreading of hypomethylated H3-K79 with resultant silencing.
Journal ArticleDOI
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
Alejandro Vaquero,Michael Scher,Dong-Hoon Lee,Ann Sutton,Hwei-Ling Cheng,Frederick W. Alt,Lourdes Serrano,Rolf Sternglanz,Danny Reinberg +8 more
TL;DR: The mammalian cytoplasmic protein SirT2 is a member of the Sir2 family of NAD+-dependent protein deacetylases involved in caloric restriction-dependent life span extension and has a strong preference for histone H4K16Ac in their de acetylation activity in vitro and in vivo.
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SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
TL;DR: It is found that SirT3 is transported from the nucleus to the mitochondria upon cellular stress, including DNA damage induced by Etoposide and UV-irradiation, as well as overexpression ofSirT3 itself.
Journal ArticleDOI
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.
Andrei Kuzmichev,Raphaël Margueron,Alejandro Vaquero,Tanja S. Preissner,Michael Scher,Antonis Kirmizis,Xuesong Ouyang,Neil Brockdorff,Cory Abate-Shen,Peggy J. Farnham,Danny Reinberg +10 more
TL;DR: Findings suggest that formation of a transformation-specific PRC complex may have a major role in resetting patterns of gene expression by regulating chromatin structure.
Journal ArticleDOI
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Alejandro Vaquero,Michael Scher,Hediye Erdjument-Bromage,Paul Tempst,Lourdes Serrano,Danny Reinberg +5 more
TL;DR: A functional link is demonstrated between the heterochromatin-related histone methyltransferase SUV39H1 and the histone deacetylase SIRT1, and these activities independently contribute to elevated levels of SUV39h1 activity resulting in increased levels of the H3K9me3 modification.