M
Michael U. Musheev
Researcher at York University
Publications - 44
Citations - 2262
Michael U. Musheev is an academic researcher from York University. The author has contributed to research in topics: DNA & Aptamer. The author has an hindex of 23, co-authored 41 publications receiving 1897 citations. Previous affiliations of Michael U. Musheev include Institute of Molecular Biotechnology.
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Journal ArticleDOI
Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures: A Universal Tool for Development of Aptamers
Maxim V. Berezovski,Andrei P. Drabovich,Svetlana M. Krylova,Michael U. Musheev,Victor Okhonin,Alexander P. Petrov,Sergey N. Krylov +6 more
TL;DR: NECEEM-based selection has exceptionally high efficiency, which allows aptamer development with fewer rounds of selection, and can potentially facilitate selection of aptamers with predefined K(d), k(off), and k(on) of the aptamer-target interaction.
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Non-SELEX Selection of Aptamers
TL;DR: For the first time, non-SELEX selection of aptamers is reported, a process that involves repetitive steps of partitioning with no amplification between them, and this work introduces an extremely fast and economical method for aptamer selection.
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Aptamer-Facilitated Biomarker Discovery (AptaBiD)
TL;DR: AptaBiD was used to discover surface biomarkers that distinguish live mature and immature dendritic cells that were proven to be highly efficient in flow- and magnetic-bead-assisted separation of mature cells from immature cells.
Journal ArticleDOI
Non-SELEX: selection of aptamers without intermediate amplification of candidate oligonucleotides.
Maxim V. Berezovski,Michael U. Musheev,Andrei P. Drabovich,Julia Jitkova,Julia Jitkova,Sergey N. Krylov +5 more
TL;DR: A protocol for non-SELEX selection of aptamers — a process that involves repetitive steps of partitioning with no amplification between them, which can be completed in 1 wk, whereas conventional SELEX protocols take several weeks even in a specialized industrial facility.
Journal ArticleDOI
GADD45A binds R-loops and recruits TET1 to CpG island promoters.
Khelifa Arab,Emil Karaulanov,Michael U. Musheev,Philipp Trnka,Andrea I. Schäfer,Ingrid Grummt,Christof Niehrs +6 more
TL;DR: It is proposed that GADD45A is an epigenetic R-loop reader that recruits the demethylation machinery to promoter CGIs and mediates local DNA dem methylation by recruiting TET1.