Michael W. Lopresti

TL;DR: Results support a model in which structured RNA negatively regulates the potentially harmful DNA deamination activity of APOBEC3H while, at the same time, positively regulating its antiviral activity.

TL;DR: It is shown that the well-established pathway of lysosomal fusion to the plasma membrane is the primary route for the disposal of FAs derived from lipophagy and may play an important role in cell-to-cell lipid exchange and signaling.

TL;DR: Data show that PLIN5 signals via SIRT1 to promote autophagy and prevent FA-induced inflammation as a means to maintain hepatocyte homeostasis during periods of fasting and FA mobilization.

TL;DR: In this article, PHLPP2 was found to suppress a survival response mediated through AMP signaling in T-leukemia cells subjected to metabolic stress from glucose limitation, rather than Akt or S6K.

TL;DR: The role of RNA in APOBEC3H regulation is addressed and a mechanism in which double-stranded RNA mediates enzyme dimerization mechanism is demonstrated, suggesting mechanistic conservation and relevance to innate and adaptive immunity and to multiple diseases.