M
Michael W. White
Researcher at University of South Florida
Publications - 102
Citations - 6037
Michael W. White is an academic researcher from University of South Florida. The author has contributed to research in topics: Toxoplasma gondii & Gene. The author has an hindex of 39, co-authored 98 publications receiving 5492 citations. Previous affiliations of Michael W. White include Montana State University & Elmhurst College.
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Journal ArticleDOI
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
Jeroen P. J. Saeij,S. Coller,Jon P. Boyle,Maria E. Jerome,Michael W. White,John C. Boothroyd +5 more
TL;DR: This work uses genetic crosses between type II and III lines to show that strain-specific differences in the modulation of host cell transcription are mediated by a putative protein kinase, ROP16, and provides a new mechanism for how an intracellular eukaryotic pathogen can interact with its host.
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A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.
Sonya Taylor,Antonio Barragan,Antonio Barragan,Chunlei Su,Chunlei Su,Blima Fux,Sarah J. Fentress,Keliang Tang,Wandy L. Beatty,H. El Hajj,Maria E. Jerome,Michael S. Behnke,Michael W. White,John C. Wootton,L.D. Sibley +14 more
TL;DR: Genetic mapping revealed two closely adjacent quantitative trait loci on parasite chromosome VIIa that control the extreme virulence of the type I lineage and identified the candidate virulence gene ROP18, a highly polymorphic serine-threonine kinase that was secreted into the host cell during parasite invasion.
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Bleaching in reef corals: Physiological and stable isotopic responses
TL;DR: During the late summer to fall of 1987, Caribbean reef corals experienced an intense and widespread discoloration event described as bleaching, Contrary to initial predictions, most bleached corals did not die and energy input from zooxanthellae decreased.
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Coordinated Progression through Two Subtranscriptomes Underlies the Tachyzoite Cycle of Toxoplasma gondii
Michael S. Behnke,Michael S. Behnke,John C. Wootton,Margaret M. Lehmann,Joshua B. Radke,Joshua B. Radke,Olivier Lucas,Julie Nawas,L. David Sibley,Michael W. White,Michael W. White +10 more
TL;DR: The mechanisms responsible for cyclical gene expression timing are likely crucial to the efficiency of parasite replication and may provide new avenues for interfering with parasite growth.
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A Systematic Screen to Discover and Analyze Apicoplast Proteins Identifies a Conserved and Essential Protein Import Factor
Lilach Sheiner,Jessica L. Demerly,Nicole Poulsen,Wandy L. Beatty,Olivier Lucas,Michael S. Behnke,Michael W. White,Boris Striepen +7 more
TL;DR: Phenotypic analysis of this mutant is consistent with a role of the PPP1 protein in apicoplast biogenesis, specifically in import of nuclear-encoded proteins into the organelle, and suggests that this peripheral plastid protein, PPP 1, is likely localized to the periplastid compartment.