W
Wandy L. Beatty
Researcher at Washington University in St. Louis
Publications - 108
Citations - 11838
Wandy L. Beatty is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Chlamydia trachomatis & Intracellular parasite. The author has an hindex of 53, co-authored 96 publications receiving 10185 citations. Previous affiliations of Wandy L. Beatty include University of Wisconsin-Madison & French Institute of Health and Medical Research.
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Journal ArticleDOI
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Stanley Ching-Cheng Huang,Bart Everts,Yulia Ivanova,David O’Sullivan,Marcia Nascimento,Amber M. Smith,Wandy L. Beatty,Latisha Love-Gregory,Wing Y. Lam,Christina M. O’Neill,Cong Yan,Hong Du,Nada A. Abumrad,Joseph F. Urban,Maxim N. Artyomov,Erika L. Pearce,Edward J. Pearce +16 more
TL;DR: In this article, the authors found that the uptake of triacylglycerol substrates via the scavenger receptor CD36 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of elevated oxidative phosphorylation, enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together define M2 activation.
Journal ArticleDOI
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Tyler K. Ulland,Wilbur M. Song,Stanley Ching-Cheng Huang,Jason D. Ulrich,Alexey Sergushichev,Wandy L. Beatty,Alexander A. Loboda,Yingyue Zhou,Nigel J. Cairns,Amal Kambal,Ekaterina Loginicheva,Susan Gilfillan,Marina Cella,Herbert W. Virgin,Emil R. Unanue,Yaming Wang,Maxim N. Artyomov,David M. Holtzman,Marco Colonna +18 more
TL;DR: Dietary cyclocreatine tempered autophagy, restored microglial clustering around plaques, and decreased plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology, finding that TREM1 enables microglia responses during AD by sustaining cellular energetic and biosynthetic metabolism.
Journal ArticleDOI
Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis.
TL;DR: In vitro studies of chlamydial persistence are evaluated and model systems associated with altered growth suggest an innate flexibility in the developmental cycle of Chlamydiae.
Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation
Stanley Ching-Cheng Huang,Bart Everts,Yulia Ivanova,David O’Sullivan,Marcia Nascimento,Amber M. Smith,Wandy L. Beatty,Latisha Love-Gregory,Wing Y. Lam,Christina M. O’Neill,Cong Yan,Hong Du,Nada A. Abumrad,Joseph F. Urban,Maxim N. Artyomov,Erika L. Pearce,Edward J. Pearce +16 more
TL;DR: It is found that the uptake of triacylglycerol substrates via the scavenger receptor CD36 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of elevated oxidative phosphorylation, enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together define M2 activation.
Journal ArticleDOI
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.
Sonya Taylor,Antonio Barragan,Antonio Barragan,Chunlei Su,Chunlei Su,Blima Fux,Sarah J. Fentress,Keliang Tang,Wandy L. Beatty,H. El Hajj,Maria E. Jerome,Michael S. Behnke,Michael W. White,John C. Wootton,L.D. Sibley +14 more
TL;DR: Genetic mapping revealed two closely adjacent quantitative trait loci on parasite chromosome VIIa that control the extreme virulence of the type I lineage and identified the candidate virulence gene ROP18, a highly polymorphic serine-threonine kinase that was secreted into the host cell during parasite invasion.