Michael Zimmer

TL;DR: Compensatory pathways can be activated to preserve the tumor angiogenic response, and strategies that inhibit HIF-1α may be most effective when IL-8 is simultaneously targeted.

TL;DR: The data suggest that deregulation of hypoxia-inducible genes in VHL-/- cells can be attributed mainly to deregulation of HIF and validate HIF as a therapeutic anticancer drug target.

TL;DR: This chemical genetic analysis describes a molecular mechanism by which translation of the HIF-2a message is maintained during conditions of cellular hypoxia through inhibition of IRP-1-dependent repression.

TL;DR: Hypoxia induced VEGF promoter activity, mRNA, and protein levels in colon cancer cells and the introduction of K-rasVal12 augmented the hypoxic induction of V EGF, suggesting the existence of multiple mechanisms regulating the Hypoxia-inducible factor-1 (HIF-1) transcription factor's induction by hypoxia.

TL;DR: Expansion of the D4S43 region to include 108 kilobases of cloned DNA has allowed identification of eight restriction fragment length polymorphisms and at least two independent coding segments, which must be considered candidates for the site of the HD defect.