H
Hans Lehrach
Researcher at Lincoln's Inn
Publications - 72
Citations - 10894
Hans Lehrach is an academic researcher from Lincoln's Inn. The author has contributed to research in topics: Gene mapping & Gene. The author has an hindex of 35, co-authored 72 publications receiving 10397 citations. Previous affiliations of Hans Lehrach include European Bioinformatics Institute & French Institute of Health and Medical Research.
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Journal ArticleDOI
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
Marcy E. MacDonald,Christine Ambrose,Mabel P. Duyao,Richard H. Myers,Carol Lin,Lakshmi Srinidhi,Glenn Barnes,Sherryl A.M. Taylor,Marianne James,Nicolet Groot,Heather MacFarlane,Barbara Jenkins,Mary Anne Anderson,Nancy S. Wexler,James F. Gusella,Gillian P. Bates,Sarah Baxendale,Holger Hummerich,Susan F. Kirby,Mike North,S. Youngman,Richard Mott,Günther Zehetner,Zdenek Sedlacek,Annemarie Poustka,Anna-Maria Frischauf,Hans Lehrach,Alan Buckler,Deanna M. Church,Lynn Doucette-Stamm,Michael Conlon O'Donovan,Laura Riba-Ramirez,Manish A. Shah,Vincent P. Stanton,Scott A. Strobel,Karen M. Draths,Jennifer L. Wales,Peter B. Dervan,David E. Housman,Michael R. Altherr,Rita Shiang,Leslie M. Thompson,Thomas J. Fielder,John J. Wasmuth,Danilo A. Tagle,John Valdes,Lawrence W. Elmer,Marc W. Allard,Lucio H. Castilla,Manju Swaroop,Kris Blanchard,Francis S. Collins,Russell G. Snell,Tracey Holloway,Kathleen Gillespie,Nicole A. Datson,Duncan Shaw,Peter S. Harper +57 more
TL;DR: In this article, the authors used haplotype analysis of linkage disequilibrium to spotlight a small segment of 4p16.3 as the likely location of the defect, which is expanded and unstable on HD chromosomes.
Journal ArticleDOI
Structure and expression of the Huntington's disease gene: Evidence against simple inactivation due to an expanded CAG repeat
Christine Ambrose,Mabel P. Duyao,Glenn Barnes,Gillian P. Bates,Carol Lin,Jayalakshmi Srinidhi,Sarah Baxendale,Holger Hummerich,Hans Lehrach,Michael R. Altherr,John J. Wasmuth,Alan Buckler,Deanna Church,David E. Housman,Mary Berks,Gos Micklem,Richard Durbin,Alan Dodge,Andrew P Read,James F. Gusella,Marcy E. MacDonald +20 more
TL;DR: Observations suggest that the dominant HD mutation either confers a new property on the mRNA or alters an interaction at the protein level, suggesting the operation of interacting factors in determining specificity of cell loss.
Journal ArticleDOI
Hybridization analyses of arrayed cDNA libraries
Gregory G. Lennon,Hans Lehrach +1 more
Journal ArticleDOI
Large-Scale Clustering of cDNA-Fingerprinting Data
Ralf Herwig,Albert J. Poustka,Christine H. Müller,Christof Bull,Hans Lehrach,John T. O'Brien +5 more
TL;DR: A pairwise similarity measure between two p-dimensional data points, x and y, is introduced that is superior to commonly used metric distances, for example, Euclidean distance and a modified version of mutual information is introduced as a novel method for validating clustering results when the true clustering is known.
Journal ArticleDOI
Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire
Nissim Ben-Arie,Doron Lancet,Clare Taylor,Miriam Khen,NaomlWalker,David H. Ledbetter,Romeo Carrozzo,Ketan Patel,Denlse Sheer,Hans Lehrach,Michael A. North +10 more
TL;DR: The human chromosome 17 olfactory receptor (OR) superfamily has been identified in a number of species as discussed by the authors and the intronless coding regions are physically mapped (on 35 cosmids) in one 0.35Mb long contiguous cluster, with an average intergenic separation of 15kb.