M
Michal P. Wandel
Researcher at Laboratory of Molecular Biology
Publications - 11
Citations - 1489
Michal P. Wandel is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Replicon & Subgenomic mRNA. The author has an hindex of 7, co-authored 11 publications receiving 1180 citations. Previous affiliations of Michal P. Wandel include University of Cambridge & University of Warsaw.
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Journal ArticleDOI
Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
TL;DR: It is shown in human cells that galectin 8 (also known as LGALS8), a cytosolic lectin, is a danger receptor that restricts Salmonella proliferation and serves as a versatile receptor for vesicle-damaging pathogens.
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The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae.
Sulman Shafeeq,Hasan Yesilkaya,Tomas G. Kloosterman,Geetha Narayanan,Michal P. Wandel,Peter W. Andrew,Oscar P. Kuipers,Julie A. Morrissey +7 more
TL;DR: In this paper, a number of pneumococcal genes are differentially regulated by copper, including an operon encoding a CopY regulator, a protein of unknown function (CupA) and a P1-type ATPase, CopA which is conserved in all sequenced Streptococcus pneumoniae strains.
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Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms.
Michal P. Wandel,Bae Hoon Kim,Eui-Soon Park,Eui-Soon Park,Keith B. Boyle,Komal Nayak,Brice Lagrange,Adrian Herod,Thomas Henry,Matthias Zilbauer,John R. Rohde,John D. MacMicking,John D. MacMicking,Felix Randow,Felix Randow +14 more
TL;DR: It is shown that in interferon-γ-stimulated cells guanylate-binding proteins (GBPs) assemble on the surface of Gram-negative bacteria into polyvalent signaling platforms required for activation of caspase-4.
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GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8
Michal P. Wandel,Claudio Pathe,Emma I. Werner,Cara J. Ellison,Keith B. Boyle,Alexander von der Malsburg,John R. Rohde,Felix Randow,Felix Randow +8 more
TL;DR: An important function of GBP recruitment to S. flexneri is to prevent the spread of infection to neighboring cells while IpaH9.8 helps bacterial propagation by counteracting GBP-dependent cell-autonomous immunity.
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Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy
TL;DR: The crystal structure of the NDP52–galectin-8 complex is solved to show how NDP52 exclusively binds galectIn-8 and, consequently, why other galectins do not restrict the growth of Salmonella in human cells.