B
Brice Lagrange
Researcher at Claude Bernard University Lyon 1
Publications - 14
Citations - 834
Brice Lagrange is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Inflammasome & Pyroptosis. The author has an hindex of 10, co-authored 13 publications receiving 544 citations. Previous affiliations of Brice Lagrange include École normale supérieure de Lyon & University of Burgundy.
Papers
More filters
Journal ArticleDOI
LPS targets host guanylate‐binding proteins to the bacterial outer membrane for non‐canonical inflammasome activation
José Carlos Santos,José Carlos Santos,Mathias S. Dick,Brice Lagrange,Daniel Degrandi,Klaus Pfeffer,Masahiro Yamamoto,Etienne Meunier,Pawel Pelczar,Thomas Henry,Petr Broz,Petr Broz +11 more
TL;DR: A novel function for GBPs is revealed in controlling the intracellular detection of LPS derived from extracellular bacteria in the form of OMVs, thus extending their function as a hub between cell‐autonomous immunity and innate immunity.
Journal ArticleDOI
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms.
Michal P. Wandel,Bae Hoon Kim,Eui-Soon Park,Eui-Soon Park,Keith B. Boyle,Komal Nayak,Brice Lagrange,Adrian Herod,Thomas Henry,Matthias Zilbauer,John R. Rohde,John D. MacMicking,John D. MacMicking,Felix Randow,Felix Randow +14 more
TL;DR: It is shown that in interferon-γ-stimulated cells guanylate-binding proteins (GBPs) assemble on the surface of Gram-negative bacteria into polyvalent signaling platforms required for activation of caspase-4.
Journal ArticleDOI
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.
Brice Lagrange,Sacha Benaoudia,Pierre Wallet,Flora Magnotti,Angelina Provost,Fanny Michal,Amandine Martin,Flaviana Di Lorenzo,Bénédicte F. Py,Antonio Molinaro,Thomas Henry +10 more
TL;DR: The data demonstrate a broader reactivity of caspase-4 to under-acylated LPS than caspases-11, which may have important clinical implications for management of sepsis, and establishes that human Guanylate-binding proteins promote inflammasome responses toUnder-acylation LPS.
Journal ArticleDOI
Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia
Romain Aucagne,Nathalie Droin,Jérôme Paggetti,Brice Lagrange,Anne Largeot,Arlette Hammann,Amandine Bataille,Laurent Martin,Kai-Ping Yan,Pierre Fenaux,Régine Losson,Eric Solary,Jean-Noël Bastie,Laurent Delva +13 more
TL;DR: It is demonstrated that Tif1G is an epigenetically regulated tumor suppressor gene in hematopoietic cells and suggested that changes in TIF1γ expression may be a biomarker of response to demethylating agents in CMML.
Journal ArticleDOI
A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells
Sacha Benaoudia,Amandine Martin,Marta Puig Gamez,Brice Lagrange,Maxence Cornut,Kyrylo Krasnykov,Jean-Baptiste Claude,Cyril F. Bourgeois,Sandrine Hughes,Benjamin Gillet,Omran Allatif,Antoine Corbin,Romeo Ricci,Thomas Henry +13 more
TL;DR: A genome‐wide CRISPR/Cas9 screen in a human monocyte cell line is conducted to identify genes controlling cytosolic LPS‐mediated pyroptosis and finds that the transcription factor, IRF2, is required for pyroPTosis following cytosol LPS delivery and functions by directly regulating caspase‐4 levels in human monocytes and iPSC‐derived monocytes.