M
Matthias Zilbauer
Researcher at University of Cambridge
Publications - 88
Citations - 3893
Matthias Zilbauer is an academic researcher from University of Cambridge. The author has contributed to research in topics: Inflammatory bowel disease & DNA methylation. The author has an hindex of 28, co-authored 76 publications receiving 2474 citations. Previous affiliations of Matthias Zilbauer include Witten/Herdecke University & Cambridge University Hospitals NHS Foundation Trust.
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Journal ArticleDOI
The landscape of somatic mutation in normal colorectal epithelial cells
Henry Lee-Six,Sigurgeir Olafsson,Peter D. Ellis,Robert J. Osborne,Mathijs A. Sanders,Mathijs A. Sanders,Luiza Moore,Nikitas Georgakopoulos,Franco Torrente,Ayesha Noorani,Ayesha Noorani,Martin Goddard,Philip Robinson,Tim H. H. Coorens,Laura O’Neill,Christopher Alder,Jingwei Wang,Rebecca C. Fitzgerald,Rebecca C. Fitzgerald,Matthias Zilbauer,Nicholas Coleman,Nicholas Coleman,Kourosh Saeb-Parsy,Inigo Martincorena,Peter J. Campbell,Michael R. Stratton +25 more
TL;DR: Genome sequencing of hundreds of normal colonic crypts from 42 individuals sheds light on mutational processes and driver mutations in normal colorectal epithelial cells, indicating that adenomas and carcinomas are rare outcomes of a pervasive process of neoplastic change across morphologically normal colorean epithelium.
Journal ArticleDOI
Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids.
Marko Nikolic,Oriol Caritg,Quitz Jeng,Jo-Anne Johnson,Dawei Sun,Kate J. Howell,Kate J. Howell,Jane Brady,Usua Laresgoiti,George E. Allen,Richard Butler,Matthias Zilbauer,Adam Giangreco,Emma L. Rawlins,Emma L. Rawlins +14 more
TL;DR: It is confirmed that human and mouse tips are analogous and signalling pathways that are sufficient for long-term self-renewal of human tips as differentiation-competent organoids are identified.
Journal ArticleDOI
DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome
Kate J. Howell,Kate J. Howell,Judith Kraiczy,Komal Nayak,Marco Gasparetto,Alexander Ross,Claire Lee,Tim N. Mak,Bon-Kyoung Koo,Nitin Kumar,Trevor D. Lawley,Anupam Sinha,Philip Rosenstiel,Robert Heuschkel,Oliver Stegle,Matthias Zilbauer +15 more
TL;DR: For example, this paper analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about pathogenesis.
Journal ArticleDOI
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids
Fotios Sampaziotis,Alexander W. Justin,Olivia C. Tysoe,Stephen J. Sawiak,Edmund Godfrey,Sara Upponi,Richard L. Gieseck,Miguel Cardoso de Brito,N.L. Berntsen,María J Gómez-Vázquez,Daniel Ortmann,Loukia Yiangou,Alexander Ross,Johannes Bargehr,Alessandro Bertero,Mariëlle C. F. Zonneveld,Marianne Terndrup Pedersen,Matthias Pawlowski,Laura Valestrand,Pedro Madrigal,Nikitas Georgakopoulos,Negar Pirmadjid,Gregor Skeldon,John Casey,Wenmiao Shu,Wenmiao Shu,Paulina M. Materek,Kirsten E. Snijders,Stephanie Brown,Casey A. Rimland,Ingrid Simonic,Susan E. Davies,Kim B. Jensen,Matthias Zilbauer,William Gelson,Graeme J.M. Alexander,Sanjay Sinha,Nicholas R.F. Hannan,Thomas A. Wynn,Tom H. Karlsen,Espen Melum,Athina E. Markaki,Kourosh Saeb-Parsy,Ludovic Vallier +43 more
TL;DR: In conclusion, ECOs can successfully reconstruct the biliary tree, providing proof of principle for organ regeneration using human primary cholangiocytes expanded in vitro.
Posted ContentDOI
The landscape of somatic mutation in normal colorectal epithelial cells
Henry Lee-Six,Peter D. Ellis,Robert J. Osborne,Mathijs A. Sanders,Luiza Moore,Nikitas Georgakopoulos,Franco Torrente,Ayesha Noorani,Ayesha Noorani,Martin Goddard,Philip Robinson,Tim H. H. Coorens,Laura O’Neill,Christopher Alder,Jingwei Wang,Rebecca C. Fitzgerald,Rebecca C. Fitzgerald,Matthias Zilbauer,Nicholas Coleman,Kourosh Saeb-Parsy,Inigo Martincorena,Peter J. Campbell,Michael R. Stratton +22 more
TL;DR: Probably driver mutations were present in ∼1% of normal colorectal crypts in middle-aged individuals, indicating that adenomas and carcinomas are rare outcomes of a pervasive process of neoplastic change across morphologically normal colOREctal epithelium.