M
Michel David
Researcher at French Institute of Health and Medical Research
Publications - 76
Citations - 3111
Michel David is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Congenital adrenal hyperplasia & Virilization. The author has an hindex of 27, co-authored 76 publications receiving 2956 citations. Previous affiliations of Michel David include Claude Bernard University Lyon 1.
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Journal ArticleDOI
Prenatal treatment of congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency
Michel David,Maguelone G. Forest +1 more
TL;DR: Six mothers at risk of in utero virilization of female fetuses with 21-hydroxylase deficiency were treated with either hydrocortisone or dexamethasone in early pregnancy, with encouraging results.
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Evaluation of Gonadal Function in 107 Intersex Patients by Means of Serum Antimüllerian Hormone Measurement
Rodolfo Rey,Corinne Belville,Claire Nihoul-Fékété,Laurence Michel-Calemard,Maguelone G. Forest,Najiba Lahlou,Francis Jaubert,Irène Mowszowicz,Michel David,Nurçin Saka,Claire Bouvattier,Anne-Marie Bertrand,Claudine Lecointre,Sylvie Soskin,Sylvie Cabrol,Hélène Crosnier,Juliane Léger,Stephen Lortat-Jacob,Marc Nicolino,Wolfgang Rabl,Sergio P. A. Toledo,Firdevs Bas,Anne Gompel,Paul Czernichow,Pierre Chatelain,Raphaël Rappaport,Yves Morel,Nathalie Josso +27 more
TL;DR: Serum AMH determination is a powerful tool to assess Sertoli cell function in children with intersex states, and it helps to distinguish between defects of male sexual differentiation caused by abnormal testicular determination and those resulting from isolated impairment of testosterone secretion or action.
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Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency
Anne-Marie Pulichino,Sophie Vallette-Kasic,Catherine Couture,Yves Gauthier,Thierry Brue,Michel David,Georges Malpuech,Cheri Deal,Guy Van Vliet,Monique De Vroede,Felix G. Riepe,Carl-Joachim Partsch,Wolfgang G. Sippell,Merih Berberoğlu,Begüm Atasay,Jacques Drouin +15 more
TL;DR: In this paper, the authors defined congenital early onset IAD as a relatively homogeneous clinical entity caused by recessive transmission of loss-of-function mutations in the TPIT gene.
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Familial male pseudohermaphroditism with gynecomastia due to a testicular 17-ketosteroid reductase defect. I. Studies in vivo.
TL;DR: Prior to operation, the basal urinary excretion of estrone, estradiol and estriol was much increased above that of a normal man but it became normal after gonadectomy, and both before and after adrenal stimulation, the plasma androgens showed the pattern and concentrations of androstenedione.
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Disruption of a long distance regulatory region upstream of SOX9 in isolated disorders of sex development
Sabina Benko,Christopher T. Gordon,Delphine Mallet,Rajini Sreenivasan,Christel Thauvin-Robinet,Atle Brendehaug,Sophie Thomas,Ove Bruland,Michel David,Marc Nicolino,Audrey Labalme,Damien Sanlaville,Patrick Callier,Valérie Malan,Frédéric Huet,Anders Molven,Frédérique Dijoud,Arnold Munnich,Laurence Faivre,Jeanne Amiel,Vincent R. Harley,Gunnar Houge,Yves Morel,Stanislas Lyonnet +23 more
TL;DR: It is proposed that this region contains a gonad specific SOX9 transcriptional enhancer(s), the gain or loss of which results in genomic imbalance sufficient to activate or inactivate SoX9 gonadal expression in a tissue specific manner, switch sex determination, and result in isolated DSD.