M
Michel Ovize
Researcher at French Institute of Health and Medical Research
Publications - 279
Citations - 19720
Michel Ovize is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Myocardial infarction & Mitochondrial permeability transition pore. The author has an hindex of 65, co-authored 259 publications receiving 17756 citations. Previous affiliations of Michel Ovize include Claude Bernard University Lyon 1 & University of Lyon.
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Journal ArticleDOI
Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion.
TL;DR: Brief episodes of ischemia in one vascular bed protect remote, virgin myocardium from subsequent sustained coronary artery occlusion in this canine model, and implies that preconditioning may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemic/reperfusion.
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Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction
Christophe Piot,Pierre Croisille,P. Staat,Hélène Thibault,Gilles Rioufol,Nathan Mewton,Rachid Elbelghiti,Thien Tri Cung,Eric Bonnefoy,Denis Angoulvant,Christophe Macia,Franck Raczka,Catherine Sportouch,Gérald Gahide,Gérard Finet,Xavier André-Fouët,Didier Revel,Gilbert Kirkorian,Jean-Pierre Monassier,Geneviève Derumeaux,Michel Ovize +20 more
TL;DR: Administration of cyclosporine at the time of reperfusion was associated with a smaller infarct by some measures than that seen with placebo, and these data are preliminary and require confirmation in a larger clinical trial.
Journal ArticleDOI
Postconditioning the Human Heart
P. Staat,Gilles Rioufol,Christophe Piot,Yves Cottin,Thien Tri Cung,Isabelle L’Huillier,Jean-François Aupetit,Eric Bonnefoy,Gérard Finet,Xavier André-Fouët,Michel Ovize +10 more
TL;DR: This study suggests that postconditioning by coronary angioplasty protects the human heart during acute myocardial infarction.
Journal Article
Postconditioning the human heart
TL;DR: Ischemic postconditioning, consisting of repeated brief cycles of ischemia-reperfusion performed immediately after reperfusion following a prolonged ischemic insult, dramatically reduces infarct size in experimental models as mentioned in this paper.
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Evolving therapies for myocardial ischemia/reperfusion injury.
TL;DR: The past, present, and future therapies to reduce ischemia/reperfusion injury are examined; few interventions have successfully passed the proof-of-concept stage.