M
Michel P. Rathbone
Researcher at McMaster University
Publications - 133
Citations - 6137
Michel P. Rathbone is an academic researcher from McMaster University. The author has contributed to research in topics: Guanosine & Adenosine. The author has an hindex of 41, co-authored 129 publications receiving 5911 citations. Previous affiliations of Michel P. Rathbone include St. Joseph's Healthcare Hamilton & McMaster University Medical Centre.
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Journal ArticleDOI
A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis
Arlan H. Mintz,John R. W. Kestle,Michel P. Rathbone,Laurie E. Gaspar,Herman Hugenholtz,Barbara Fisher,Graeme Duncan,Peter Skingley,Gary Foster,Mark Levine +9 more
TL;DR: This data indicates that the addition of surgical extirpation prior to radiation therapy increased survival, neurologic function, and quality of life compared with radiation alone in patients with a single brain metastasis.
Journal ArticleDOI
Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells
Joseph T. Neary,Michel P. Rathbone,Flaminio Cattabeni,Maria P. Abbracchio,Geoffrey Burnstock +4 more
TL;DR: Receptors for nucleotides and nucleosides could represent a novel target for the development of therapeutic strategies to treat incurable diseases of the nervous system, including trauma- and ischemia-associated neurodegeneration, demyelinating and aging-associated cognitive disorders.
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Trophic effects of purines in neurons and glial cells.
Michel P. Rathbone,Pamela J. Middlemiss,J.W. Gysbers,Craig M. Andrew,Mary A. Herman,J. K. Reed,Renata Ciccarelli,P. Di Iorio,Francesco Caciagli +8 more
TL;DR: Large quantities of purines, particularly guanosine and, to a lesser extent adenosine, are released extracellularly following ischemia or trauma, and are likely to exert trophic effects in vivo following trauma.
Journal ArticleDOI
Involvement of astrocytes in purine-mediated reparative processes in the brain
R. Ciccarelli,P. Ballerini,G Sabatino,Michel P. Rathbone,Monica D'Onofrio,Francesco Caciagli,P. Di Iorio +6 more
TL;DR: Data indicate that adenine‐ and guanine‐based purines released in large amounts from injured or dying cells of CNS may act as signals to initiate brain repair mechanisms widely involving astrocytes.
Journal ArticleDOI
Nitric oxide donors enhance neurotrophin-induced neurite outgrowth through a cGMP-dependent mechanism.
Shaun Hindley,Bernhard H.J. Juurlink,J.W. Gysbers,Pamela J. Middlemiss,Mary A. Herman,Michel P. Rathbone +5 more
TL;DR: Investigation of whether NO stimulated neurite outgrowth from hippocampal neurons and PC12 cells suggested that NO may act alone or with other growth factors to regulate synapse formation and maintenance by stimulating neuriteOutgrowth.