M
Michel Pohl
Researcher at French Institute of Health and Medical Research
Publications - 50
Citations - 3040
Michel Pohl is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Spinal cord & Calcitonin gene-related peptide. The author has an hindex of 29, co-authored 50 publications receiving 2874 citations. Previous affiliations of Michel Pohl include Paris Descartes University.
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Journal ArticleDOI
A Third Vesicular Glutamate Transporter Expressed by Cholinergic and Serotoninergic Neurons
Christelle Gras,Etienne Herzog,Gian Carlo Bellenchi,Véronique Bernard,Philippe Ravassard,Michel Pohl,Bruno Gasnier,Bruno Giros,Salah El Mestikawy +8 more
TL;DR: A novel class of glutamatergic nerve terminals is revealed and it is suggested that cholinergic striatal interneurons and serotoninergic neurons from the brainstem may store and release glutamate.
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JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat
TL;DR: Data show that in response to SNL injury Janus kinase/STAT3 system is activated mainly through IL‐6 signaling in spinal microglia and that this transduction pathway participates in development of pain associated with nerve alteration.
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SOCS3-Mediated Blockade of JAK/STAT3 Signaling Pathway Reveals Its Major Contribution to Spinal Cord Neuroinflammation and Mechanical Allodynia after Peripheral Nerve Injury
TL;DR: The targeted blockade of JAK/STAT3 activity prevented the abnormal expression of IL-6, CC chemokine ligand CCL2, and activating transcription factor ATF3 induced in the spinal cord by chronic constriction injury of the sciatic nerve and substantially attenuated mechanical hypersensitivity (allodynia) in rats.
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CCL2 Released from Neuronal Synaptic Vesicles in the Spinal Cord Is a Major Mediator of Local Inflammation and Pain after Peripheral Nerve Injury
Juliette Van Steenwinckel,Annabelle Réaux-Le Goazigo,Blandine Pommier,Annie Mauborgne,Marc-André Dansereau,Patrick Kitabgi,Philippe Sarret,Michel Pohl,Stéphane Melik Parsadaniantz +8 more
TL;DR: The data demonstrate that CCL2 has the typical characteristics of a neuronal mediator involved in nociceptive signal processing and that antagonists of its receptor are promising agents from treating neuropathic pain.
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Therapeutic Efficacy in Experimental Polyarthritis of Viral-Driven Enkephalin Overproduction in Sensory Neurons
Joao M. Braz,Caroline C Beaufour,Anne Coutaux,Alberto L. Epstein,François Cesselin,Michel Hamon,Michel Pohl +6 more
TL;DR: Using recombinant herpes simplex virus containing rat PA cDNA, enkephalin overproduction is enhanced in sensory neurons of polyarthritic rats, which markedly improved locomotion and reduced hyperalgesia, and the progression of bone destruction slowed down.