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Philippe Ravassard
Researcher at University of Paris
Publications - 120
Citations - 8495
Philippe Ravassard is an academic researcher from University of Paris. The author has contributed to research in topics: Cellular differentiation & Beta cell. The author has an hindex of 42, co-authored 113 publications receiving 7539 citations. Previous affiliations of Philippe Ravassard include ICM Partners & French Institute of Health and Medical Research.
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Journal ArticleDOI
A Third Vesicular Glutamate Transporter Expressed by Cholinergic and Serotoninergic Neurons
Christelle Gras,Etienne Herzog,Gian Carlo Bellenchi,Véronique Bernard,Philippe Ravassard,Michel Pohl,Bruno Gasnier,Bruno Giros,Salah El Mestikawy +8 more
TL;DR: A novel class of glutamatergic nerve terminals is revealed and it is suggested that cholinergic striatal interneurons and serotoninergic neurons from the brainstem may store and release glutamate.
Journal ArticleDOI
The Existence of a Second Vesicular Glutamate Transporter Specifies Subpopulations of Glutamatergic Neurons
Etienne Herzog,Gian Carlo Bellenchi,Christelle Gras,Véronique Bernard,Philippe Ravassard,Cécile Bedet,Bruno Gasnier,Bruno Giros,Salah El Mestikawy +8 more
TL;DR: DNPI localized to synaptic vesicles, at synapses exhibiting classical excitatory features, and represents a novel vesicular glutamate transporter (VGLUT2), which defines distinct subsets of glutamatergic neurons.
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A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
Philippe Ravassard,Yasmine Hazhouz,Severine Pechberty,Emilie Bricout-Neveu,Mathieu Armanet,Paul Czernichow,Raphael Scharfmann +6 more
TL;DR: A robust technology for producing a functional human β cell line using targeted oncogenesis in human fetal tissue is described, which represents a unique tool for large-scale drug discovery and provide a preclinical model for cell replacement therapy in diabetes.
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Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants
Lorenzo Pasquali,Kyle J. Gaulton,Kyle J. Gaulton,Kyle J. Gaulton,Santiago A. Rodríguez-Seguí,Loris Mularoni,Irene Miguel-Escalada,Ildem Akerman,Juan J. Tena,Ignasi Moran,Carlos Gómez-Marín,Martijn van de Bunt,Martijn van de Bunt,Martijn van de Bunt,Joan Ponsa-Cobas,Natalia Castro,Takao Nammo,Inês Cebola,Javier García-Hurtado,Miguel Angel Maestro,François Pattou,Lorenzo Piemonti,Thierry Berney,Anna L. Gloyn,Anna L. Gloyn,Philippe Ravassard,José Luis Gómez Skarmeta,Ferenc Müller,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Jorge Ferrer +31 more
TL;DR: This work mapped and examined the function of human islet cis-regulatory networks and identifies genomic sequences that are targeted by islet transcription factors to drive islet-specific gene activity and shows that most such sequences reside in clusters of enhancers that form physical three-dimensional chromatin domains.
Journal ArticleDOI
Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
Ignasi Moran,Ildem Akerman,Martijn van de Bunt,Martijn van de Bunt,Ruiyu Xie,Marion Benazra,Takao Nammo,Luis Arnes,Nikolina Nakic,Javier García-Hurtado,Santiago A. Rodríguez-Seguí,Lorenzo Pasquali,Claire Sauty-Colace,Anthony Beucher,Raphael Scharfmann,Joris van Arensbergen,Paul Johnson,Paul Johnson,Andrew Berry,Clarence Lee,Timothy T. Harkins,Valery Gmyr,François Pattou,Julie Kerr-Conte,Lorenzo Piemonti,Thierry Berney,Neil A. Hanley,Anna L. Gloyn,Lori Sussel,Linda Langman,Kenneth L. Brayman,Maike Sander,Mark I. McCarthy,Mark I. McCarthy,Philippe Ravassard,Jorge Ferrer,Jorge Ferrer +36 more
TL;DR: A comprehensive strand-specific transcriptome map of human pancreatic islets and β cells is reported, and a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology are revealed.