M
Michela Taiana
Researcher at University of Milan
Publications - 20
Citations - 543
Michela Taiana is an academic researcher from University of Milan. The author has contributed to research in topics: Spinal muscular atrophy & Amyotrophic lateral sclerosis. The author has an hindex of 10, co-authored 18 publications receiving 423 citations. Previous affiliations of Michela Taiana include Carlo Besta Neurological Institute.
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Journal ArticleDOI
Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy
Giorgia Melli,Michela Taiana,Francesca Camozzi,Daniela Triolo,Paola Podini,Angelo Quattrini,Franco Taroni,Giuseppe Lauria +7 more
TL;DR: In this paper, the authors used an in vitro model of chemotherapy induced peripheral neuropathy that closely mimic the in vivo condition by exposing primary cultures of dorsal root ganglion (DRG) sensory neurons to paclitaxel and cisplatin, two widely used and highly effective chemotherapeutic drugs.
Journal ArticleDOI
Morphometry of dermal nerve fibers in human skin
Giuseppe Lauria,D. Cazzato,Carla Porretta-Serapiglia,Jordi Casanova-Molla,Michela Taiana,Paola Penza,Raffaella Lombardi,Catharina G. Faber,Ingemar S. J. Merkies +8 more
TL;DR: Dermal nerve morphometry significantly correlated with intraepidermal nerve fiber density and provided a reliable method to quantify the innervation density of dermal nerves that might improve the diagnostic yield of skin biopsy.
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R-Loops in Motor Neuron Diseases.
TL;DR: Current advancements in this field are discussed with a specific focus on motor neuron diseases associated with deregulation of R-loop structures, which can represent novel therapeutic targets for these devastating, incurable diseases.
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ALS mouse model SOD1G93A displays early pathology of sensory small fibers associated to accumulation of a neurotoxic splice variant of peripherin
Jenny Sassone,Michela Taiana,Raffaella Lombardi,Carla Porretta-Serapiglia,Mattia Freschi,Silvia Bonanno,Stefania Marcuzzo,Francesca Caravello,Caterina Bendotti,Giuseppe Lauria +9 more
TL;DR: The findings demonstrate that small-diameter DRG neurons of the ALS mouse model SOD1(G93A)display axonal stress in vitro and in vivo, thus sustaining the hypothesis that the effects of ALS disease spread beyond motor neurons, and suggest a molecular mechanism for the small fiber pathology found in ALS patients.
Journal ArticleDOI
Side and time variability of intraepidermal nerve fiber density
Giuseppe Lauria,Patrizia Dacci,Raffaella Lombardi,Daniele Cazzato,Carla Porretta-Serapiglia,Michela Taiana,Jenny Sassone,Eleonora Dalla Bella,Sara Rinaldo,Christian Lettieri,Roberto Eleopra,Grazia Devigili +11 more
TL;DR: The diagnosis of SFN can be reliably ascertained by unilateral skin biopsy at the distal site of the leg, and IENFD is not expected to vary within 3 weeks.