R
Raffaella Lombardi
Researcher at University of Texas at Austin
Publications - 57
Citations - 3389
Raffaella Lombardi is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Hypertrophic cardiomyopathy & Cardiomyopathy. The author has an hindex of 29, co-authored 57 publications receiving 2935 citations. Previous affiliations of Raffaella Lombardi include University of Texas Health Science Center at Houston & The Texas Heart Institute.
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Journal ArticleDOI
Suppression of canonical Wnt/β-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy
Eduardo Garcia-Gras,Raffaella Lombardi,Michael J. Giocondo,James T. Willerson,Michael D. Schneider,Dirar S. Khoury,Ali J. Marian +6 more
TL;DR: It is shown that cardiac-restricted deletion of Dsp, encoding DP, impairs cardiac morphogenesis and leads to high embryonic lethality in the homozygous state, which provides for a novel molecular mechanism for the pathogenesis of ARVC.
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The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy
Suet Nee Chen,Priyatansh Gurha,Raffaella Lombardi,Alessandra Ruggiero,James T. Willerson,Ali J. Marian +5 more
TL;DR: Molecular remodeling of the intercalated discs leads to pathogenic activation of the Hippo pathway, suppression of the canonical Wnt signaling, and enhanced adipogenesis in AC.
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Myocardial Collagen Turnover in Hypertrophic Cardiomyopathy
Raffaella Lombardi,Sandro Betocchi,Maria Angela Losi,Carlo G. Tocchetti,Mariano Aversa,Marianna Miranda,Gianluigi D'Alessandro,Alessandra Cacace,Quirino Ciampi,Massimo Chiariello +9 more
TL;DR: As collagen I synthesis prevails over degradation and M MP-1 and MMP-2 are inhibited, passive diastolic dysfunction occurs in patients with HCM.
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Myozenin 2 Is a Novel Gene for Human Hypertrophic Cardiomyopathy
Adriana Osio,Lily Tan,Suet Nee Chen,Raffaella Lombardi,Sherif F. Nagueh,Sanjay Shete,Robert Roberts,James T. Willerson,Ali J. Marian +8 more
TL;DR: Myozenin 2 (MYOZ2) is a novel causal gene for human HCM, and its mutations affect highly conserved amino acids.
Journal ArticleDOI
Genetic Fate Mapping Identifies Second Heart Field Progenitor Cells As a Source of Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy
Raffaella Lombardi,Jinjiang Dong,Gabriela Rodriguez,Achim Bell,Tack Ki Leung,Robert J. Schwartz,James T. Willerson,Ramon Brugada,Ali J. Marian +8 more
TL;DR: Ad adipocytes in arrhythmogenic right ventricular cardiomyopathy originate from the second heart field cardiac progenitors, which switch to an adipogenic fate because of suppressed canonical Wnt signaling by nuclear plakoglobin.