M
Michele Bortolomeazzi
Researcher at King's College London
Publications - 12
Citations - 499
Michele Bortolomeazzi is an academic researcher from King's College London. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 3, co-authored 7 publications receiving 208 citations. Previous affiliations of Michele Bortolomeazzi include Francis Crick Institute.
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Journal ArticleDOI
The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens
Dimitra Repana,Dimitra Repana,Joel Nulsen,Joel Nulsen,Lisa Dressler,Lisa Dressler,Michele Bortolomeazzi,Michele Bortolomeazzi,Santhilata Kuppili Venkata,Santhilata Kuppili Venkata,Aikaterini Tourna,Aikaterini Tourna,Anna Yakovleva,Anna Yakovleva,Tommaso Palmieri,Tommaso Palmieri,Francesca D. Ciccarelli,Francesca D. Ciccarelli +17 more
TL;DR: The Network of Cancer Genes is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles, and annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, and protein function and essentiality.
Posted ContentDOI
The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens
Santhilata Kuppili Venkata,Dimitra Repana,Joel Nulsen,Lisa Dressler,Michele Bortolomeazzi,Aikaterini Tourna,Anna Yakovleva,Tommaso Palmieri,Francesca D. Ciccarelli +8 more
TL;DR: The Network of Cancer Genes is a manually curated repository of 2,372 genes whose somatic modifications have a known or predicted cancer driver role, and annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, protein function and essentiality.
Journal ArticleDOI
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.
Michele Bortolomeazzi,Michele Bortolomeazzi,Mohamed Reda Keddar,Mohamed Reda Keddar,Lucia Montorsi,Lucia Montorsi,Amelia Acha-Sagredo,Amelia Acha-Sagredo,Lorena Benedetti,Lorena Benedetti,Damjan Temelkovski,Damjan Temelkovski,Subin Choi,Subin Choi,Nedyalko Petrov,Katrina Todd,Patty Wai,Johannes Kohl,Tamara Denner,Emma Nye,Robert L. Goldstone,Sophia Ward,Gareth A. Wilson,Gareth A. Wilson,Maise Al Bakir,Maise Al Bakir,Charles Swanton,Charles Swanton,Susan D. John,James Miles,Banafshé Larijani,Banafshé Larijani,Victoria Kunene,Elisa Fontana,Hendrik Tobias Arkenau,Hendrik Tobias Arkenau,Peter J. Parker,Peter J. Parker,Manuel Rodriguez-Justo,Kai Keen Shiu,Jo Spencer,Francesca D. Ciccarelli,Francesca D. Ciccarelli +42 more
TL;DR: In this article, an integrated study of the cancer tissue and associated tumor microenvironment (TME) from patients treated with pembrolizumab (KEYNOTE 177 clinical trial) or nivolumab was conducted to dissect the cellular and molecular determinants of response to anti-programmed cell death 1 (PD1) immunotherapy.
Journal ArticleDOI
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Lisa Dressler,Michele Bortolomeazzi,Mohamed Reda Keddar,Hrvoje Misetic,G. Sartini,Amelia Acha-Sagredo,Lucia Montorsi,Neshika Wijewardhane,Dimitra Repana,Joel Nulsen,Jacki Goldman,M.S Pollitt,Patrick Davis,Amy Strange,Karen Ambrose,Francesca D. Ciccarelli +15 more
TL;DR: In this paper , the authors collected a literature-based repertoire of 3355 well-known or predicted drivers of cancer and non-cancer somatic evolution in 122 cancer types and 12 noncancer tissues.
Journal ArticleDOI
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Lisa Dressler,Michele Bortolomeazzi,Mohamed Reda Keddar,Hrvoje Misetic,G. Sartini,Amelia Acha-Sagredo,Lucia Montorsi,Neshika Wijewardhane,Dimitra Repana,Joel Nulsen,Jacki Goldman,M.S Pollitt,Patrick Davis,Amy Strange,Karen Ambrose,Francesca D. Ciccarelli +15 more
TL;DR: In this paper , the authors collected a literature-based repertoire of 3355 well-known or predicted drivers of cancer and non-cancer somatic evolution in 122 cancer types and 12 noncancer tissues.