S
Susan D. John
Researcher at King's College London
Publications - 141
Citations - 6714
Susan D. John is an academic researcher from King's College London. The author has contributed to research in topics: STAT protein & Binding site. The author has an hindex of 38, co-authored 136 publications receiving 6096 citations. Previous affiliations of Susan D. John include University of Texas Health Science Center at Houston & Memorial Hermann Healthcare System.
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Journal ArticleDOI
The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
Jian-Xin Lin,Thi-Sau Migone,Monica Tseng,Michael Friedmann,James A. Weatherbee,Li Zhou,Akira Yamauchi,Eda T. Bloom,Judy A. Mietz,Susan D. John,Warren J. Leonard +10 more
TL;DR: These studies demonstrate that a single cytokine can activate different combinations of Stat proteins under different physiological conditions, and also indicate two mechanisms by which distinct cytokines can activate the same Stat protein.
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CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
Machteld M. Tiemessen,Ann L. Jagger,Hayley G. Evans,Martijn J. C. van Herwijnen,Susan D. John,Leonie S. Taams +5 more
TL;DR: Mechanistic studies reveal that CD4+CD25+CD127lowFoxp3+ Tregs produce IL-10, IL-4, and IL-13 and that these cytokines are the critical factors involved in the suppression of the proinflammatory cytokine response.
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Functional analysis of a growth factor-responsive transcription factor complex
TL;DR: These experiments provide direct evidence that SRF and Elk-1 functionally cooperate in the ternary complex at the SRE to regulate transcription.
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Functional Association of Nmi with Stat5 and Stat1 in IL-2- and IFN γ-Mediated Signaling
TL;DR: The data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors.
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Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.
Susan D. John,R. B. Reeves,Jian-Xin Lin,R. Child,J. M. Leiden,C. B. Thompson,Warren J. Leonard +6 more
TL;DR: The characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y) and provides significant new insights into the protein-protein and protein-DNA interactions that regulate cell-type-specific and inducible IL-2R alpha gene expression.