Michele Dileone

TL;DR: A series of direct recordings of the corticospinal volley evoked by the different techniques of transcranial stimulation from the epidural space of conscious patients with chronically implanted spinal electrodes provide insights about the physiological basis of the excitatory and inhibitory phenomena produced by transcranials stimulation.

TL;DR: Results show that cTBS preferentially decreases the amplitude of the corticospinal I1 wave, with approximately the same time course as other protocols that lead to MEP suppression, such as short‐interval intracortical inhibition.

TL;DR: Whether the main characteristics of the activity evoked by single- and paired-pulse and repetitive TMS, can be accounted by the interaction of the induced currents in the brain with the key anatomic features of a simple cortical circuit, which represents the minimum architecture necessary for capturing the most essential cortical input-output operations of neocortex is evaluated.

TL;DR: ITBS affects the excitability of excitatory synaptic inputs to pyramidal tract neurones that are recruited by a TMS pulse, both in the stimulated hemisphere and in the contralateral hemisphere, however the circuits affected differ from those influenced by the inhibitory, cTBS, protocol.

TL;DR: The results are consistent with an impaired efficiency of some intracortical circuits in old age.