M
Michele Portoghese
Researcher at University of Sassari
Publications - 22
Citations - 1246
Michele Portoghese is an academic researcher from University of Sassari. The author has contributed to research in topics: Myocardial infarction & Medicine. The author has an hindex of 14, co-authored 19 publications receiving 1073 citations.
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Journal ArticleDOI
Effects of Stress Hyperglycemia on Acute Myocardial Infarction: Role of inflammatory immune process in functional cardiac outcome
Raffaele Marfella,Mario Siniscalchi,Katherine Esposito,Ausilia Sellitto,Umberto De Fanis,Ciro Romano,Michele Portoghese,Silvio Siciliano,Francesco Nappo,Ferdinando Carlo Sasso,Nicola Mininni,Federico Cacciapuoti,Giacomo Lucivero,Riccardo Giunta,Mario Verza,Dario Giugliano +15 more
TL;DR: An increased inflammatory immune process seems a likely mechanism linking acute hyperglycemia to poor cardiac outcome in MI patients.
Journal ArticleDOI
Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome
Raffaele Marfella,Clara Di Filippo,Michele Portoghese,Michelangela Barbieri,Franca Ferraraccio,Mario Siniscalchi,Federico Cacciapuoti,Francesco Rossi,Michele D'Amico,Giuseppe Paolisso +9 more
TL;DR: SREBP-1c may contribute to heart dysfunction by promoting lipid accumulation within myocytes in MS patients with AS; SREBP/peroxisome proliferator activated receptor-&ggr; protein may do it by increasing the levels of PPAR&ggR; protein.
Journal ArticleDOI
The Ubiquitin-Proteasome System and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Rosiglitazone Treatment
Raffaele Marfella,Michele D'Amico,Katherine Esposito,Alfonso Baldi,Clara Di Filippo,Mario Siniscalchi,Ferndinando Carlo Sasso,Michele Portoghese,Francesca Cirillo,Federico Cacciapuoti,Ornella Carbonara,Basilio Crescenzi,Feliciano Baldi,Antonio Ceriello,Giovanni Francesco Nicoletti,Francesco D'Andrea,Mario Verza,Ludovico Coppola,Francesco Rossi,Dario Giugliano +19 more
TL;DR: The inhibition of ubiquitin-proteasome activity in atherosclerotic lesions of diabetic patients by rosiglitazone is associated with morphological and compositional characteristics of a potential stable plaque phenotype, possibly by downregulating NF-kappaB-mediated inflammatory pathways.
Journal ArticleDOI
Tight glycemic control reduces heart inflammation and remodeling during acute myocardial infarction in hyperglycemic patients.
Raffaele Marfella,Clara Di Filippo,Michele Portoghese,Franca Ferraraccio,Maria Rosaria Rizzo,Mario Siniscalchi,Emilio Musacchio,Michele D'Amico,Francesco Rossi,Giuseppe Paolisso +9 more
TL;DR: Tight glycemic control, by reducing oxidative stress and inflammation, might reduce apoptosis in peri-infarcted areas and remodeling in AMI patients.
Journal ArticleDOI
Expression of Angiogenic Factors During Acute Coronary Syndromes in Human Type 2 Diabetes
Raffaele Marfella,Katherine Esposito,Francesco Nappo,Mario Siniscalchi,Ferdinando Carlo Sasso,Michele Portoghese,Maria Marino,Alfonso Baldi,Salvatore Cuzzocrea,Clara Di Filippo,Guglielmo Barboso,Feliciano Baldi,Francesco Rossi,Michele D'Amico,Dario Giugliano +14 more
TL;DR: Insufficient angiogenic response to ischemia in diabetic myocardium could result in poor collateral formation and diabetes is associated with increased myocardial tissue levels of iNOS, O(2)(-), and nitrotyrosine and reduced expression ofMyocardial angiogenesis factors during ischemIA.