M
Michelle L. Zaharik
Researcher at University of British Columbia
Publications - 9
Citations - 859
Michelle L. Zaharik is an academic researcher from University of British Columbia. The author has contributed to research in topics: Salmonella enterica & Salmonella. The author has an hindex of 8, co-authored 9 publications receiving 797 citations.
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Journal ArticleDOI
The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen
TL;DR: The cloning and characterization of the single NRAMP genes in Escherichia coli and Salmonella enterica ssp.
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Disruption of the Salmonella-Containing Vacuole Leads to Increased Replication of Salmonella enterica Serovar Typhimurium in the Cytosol of Epithelial Cells
TL;DR: The requirement of the host cell endosomal system for maintenance of the SCV is demonstrated and that loss of this compartment allows increased replication of serovar Typhimurium in the cytosol of epithelial cells.
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The Salmonella enterica Serovar Typhimurium Divalent Cation Transport Systems MntH and SitABCD Are Essential for Virulence in an Nramp1G169 Murine Typhoid Model
Michelle L. Zaharik,Vivian Li Cullen,Angela M. Fung,Stephen J. Libby,Sonya L. Kujat Choy,Bryan Coburn,David G. Kehres,Michael E. Maguire,Ferric C. Fang,B. Brett Finlay +9 more
TL;DR: It is demonstrated that sitA and mntH, genes encoding high-affinity metal ion uptake systems in Salmonella enterica serovar Typhimurium, are upregulated when Salmoneella is internalized by Nramp1-expressing macrophages and play an essential role in systemic infection of congenic Nramps1- expressing mice.
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Host-pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes.
TL;DR: The presence of a previously undescribed direct influence of a mammalian innate host resistance locus on a pathogen at the genetic level is demonstrated and suggested to be essential for regulating the course of an infection.
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Delivery of dangerous goods: type III secretion in enteric pathogens.
TL;DR: The following is a brief review of the way in which TTSSs and their effectors contribute to the pathogenic nature of the prototypic diarrheal pathogens Salmonella, Shigella, Yersinia and enteropathogenic Escherichia coli.