S
Samantha Gruenheid
Researcher at McGill University
Publications - 90
Citations - 6292
Samantha Gruenheid is an academic researcher from McGill University. The author has contributed to research in topics: Citrobacter rodentium & Virulence. The author has an hindex of 29, co-authored 80 publications receiving 5760 citations. Previous affiliations of Samantha Gruenheid include National Autonomous University of Mexico & University of British Columbia.
Papers
More filters
Journal ArticleDOI
Dissecting virulence: Systematic and functional analyses of a pathogenicity island
Wanyin Deng,José L. Puente,Samantha Gruenheid,Yuling Li,Bruce A. Vallance,Alejandra Vázquez,Jeannette Barba,J. Antonio Ibarra,Paul O'Donnell,Pavel Metalnikov,Keith Ashman,Sansan Lee,David L Goode,Tony Pawson,B. Brett Finlay +14 more
TL;DR: This work systematically mutagenized all 41 CR LEE genes and functionally characterized these mutants in vitro and in a murine infection model, identifying 33 virulence factors, including two virulence regulators and a hierarchical switch for type III secretion.
Journal ArticleDOI
Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome
TL;DR: The targeting of Nramp1 from endocytic vesicles to the phagosomal membrane supports the hypothesis that Nramps1 controls the replication of intracellular parasites by altering the intravacuolar environment of the microbe-containing phagosome.
Journal ArticleDOI
Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron.
François Canonne-Hergaux,Samantha Gruenheid,Samantha Gruenheid,Prem Ponka,Prem Ponka,Philippe Gros,Philippe Gros +6 more
TL;DR: Immunoblotting experiments with membrane fractions from intact organs and immunostaining studies of tissue sections suggest that Nramp2 is indeed responsible for transferrin-independent iron uptake in the duodenum and overall mechanisms of iron acquisition by the body are discussed.
Journal ArticleDOI
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells.
Samantha Gruenheid,Rebekah DeVinney,Rebekah DeVinney,Friedhelm Bladt,Danika L. Goosney,Sigal Gelkop,Gerald D. Gish,Tony Pawson,B. Brett Finlay +8 more
TL;DR: It is shown that tyrosine 474 of Tir directly binds the host-cell adaptor protein Nck, and that Nck is required for the recruitment of both neural Wiskott–Aldrich-syndrome protein (N-WASP) and the actin-related protein (Arp)2/3 complex to the EPEC pedestal, directly linking Tir to the cytoskeleton.
Journal ArticleDOI
Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1 −/− mice
Diana Matheoud,Tyler Cannon,Aurore Voisin,Anna-Maija Penttinen,Lauriane Ramet,Ahmed M. Fahmy,Charles Ducrot,Annie Laplante,Marie-Josée Bourque,Lei Zhu,Romain Cayrol,Armelle Le Campion,Heidi M. McBride,Samantha Gruenheid,Louis-Eric Trudeau,Michel Desjardins +15 more
TL;DR: Intestinal infection with Gram-negative bacteria in Pink1 −/− mice engages mitochondrial antigen presentation and autoimmune mechanisms that elicit the establishment of cytotoxic mitochondria-specific CD8+ T cells in the periphery and in the brain, supporting the idea that PINK1 is a repressor of the immune system.